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• W2040384474 abstract "A new furoquinolinone derivative, 1-(3'-hydroxypropyl)-4,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HPFQ, 4), was prepared, in which the nitrogen atom in position 1 carries a hydroxypropyl chain. The antiproliferative activity of HPFQ was studied in comparison with its analogue 1,4,6,8-tetramethylfuro[2,3-h]quinolin-2(1H)-one (FQ) and 8-methoxypsoralen (8-MOP). By incubation in the dark, HPFQ, although retaining antitopoisomerase II activity, appeared less effective than FQ. Upon UVA irradiation, HPFQ produced little amounts of singlet oxygen, but detectable levels of superoxide anion; like FQ, HPFQ induced numbers of DNA-protein cross-links, but no interstrand cross-links in mammalian cells. The HPFQ phototoxicity was comparable to that of FQ and 8-MOP, while mutagenic activity, scored in two Escherichia coli strains, seemed much less remarkable." @default.
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• W2040384474 date "2000-11-01" @default.
• W2040384474 modified "2023-10-17" @default.
• W2040384474 title "Photobiological properties of 1-(3′-hydroxypropyl)-4,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one, a new furocoumarin analogue" @default.
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• W2040384474 doi "https://doi.org/10.1016/s0014-827x(00)00091-4" @default.
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