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- W2040384914 abstract "Background: Cases of discordant responses in multiple myeloma (MM) patients after thalidomide therapy have been sometimes reported, in which extramedullary masses progress or present de novo with a simultaneous serum monoclonal protein reduction. Patients and Methods: We hereby report, for the first time, on two cases of MM patients with extramedullary myeloma localizations that developed during Velcade (bortezomib, PS341) treatment with a concomitant serum monoclonal protein reduction. Results: We observed in both patients a very good response in the serum monoclonal protein level, while extramedullary lesions appeared in the central nervous system and subcutaneously. Conclusions: We discuss pharmacokinetics of bortezomib and physiopathology of this unusual event and review the literature." @default.
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- W2040384914 date "2008-01-01" @default.
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- W2040384914 title "Unusual Discordant Responses in Two Multiple Myeloma Patients during Bortezomib Treatment" @default.
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- W2040384914 doi "https://doi.org/10.1159/000112217" @default.
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