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- W2040384992 abstract "To the Editor.— The communication concerned with the Toxic Effects of Local Anesthetics by Rudolph H. de Jong, MD (239:1166, 1978), briefly reviews some of the CNS effects of these agents and suggests that convulsions may be one consequence of increased levels made available to the brain. It should be noted, however, that in lower dose these same local anesthetics, rather than being proconvulsants or decreasing seizure threshold, serve as anticonvulsants1; this effect has been observed in the use of intravenous lidocaine in controlling status epilepticus in man, attenuating electrically-induced seizures in man,2and blocking auditory convulsions in animals.3 Certainly there is a considerable overlap between the therapeutic range of such a local anesthetic as lidocaine in the treatment of ventricular arrhythmias and ventricular tachycardia and the clinical efficacy, within the same dose range, of this agent as an anticonvulsant." @default.
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- W2040384992 date "1978-09-08" @default.
- W2040384992 modified "2023-09-27" @default.
- W2040384992 title "Anticonvulsant Effects of Local Anesthetics" @default.
- W2040384992 cites W1970932516 @default.
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- W2040384992 doi "https://doi.org/10.1001/jama.1978.03290110036006" @default.
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