FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040390621> ?p ?o ?g. }

• W2040390621 endingPage "572" @default.
• W2040390621 startingPage "563" @default.
• W2040390621 abstract "Despite vaccination campaigns, brucellosis is still one of the most common bacterial zoonosis in the world. This work describes the development of a novel formulation strategy to the delivery of the Brucella ovis antigenic extract (HS) into ovine mucosal surfaces. Thus, HS was entrapped in conventional and mannosylated poly(anhydride) nanoparticles by the solvent displacement method, and the resulting nanosystems were gamma-irradiated to accomplish the sterilization required for the ophthalmic administration route. Sterilization, at either 10 kGy or 25 kGy, did not modify the size, morphology and antigen content of the nanoparticles. Similarly, the integrity and antigenicity of the entrapped antigen were not affected by gamma-irradiation. The 25 kGy gamma-irradiation dose seemed to influence negatively the HS release from the carriers. However, and in accordance with the Pearson's correlation, all the release patterns followed a similar tendency. Furthermore, the stability of the vaccine systems on lachrymal and nasal ovine fluids, showed that gamma-irradiation had no significant effects on the vaccine systems. Since all the vaccine systems accomplished the pharmacopoeial biological tests required for gamma-irradiation doses under 25 kGy, these results are highly suggestive for the use of HS loaded poly(anhydride) nanoparticles as an efficient vaccine delivery system for brucellosis immunoprophylaxis, especially for ophthalmic administration." @default.
• W2040390621 created "2016-06-24" @default.
• W2040390621 creator A5000547718 @default.
• W2040390621 creator A5029219877 @default.
• W2040390621 creator A5070452365 @default.
• W2040390621 date "2009-07-01" @default.
• W2040390621 modified "2023-10-12" @default.
• W2040390621 title "Design and influence of γ-irradiation on the biopharmaceutical properties of nanoparticles containing an antigenic complex from Brucella ovis" @default.
• W2040390621 cites W142136517 @default.
• W2040390621 cites W1513682251 @default.
• W2040390621 cites W1940749008 @default.
• W2040390621 cites W1966009267 @default.
• W2040390621 cites W1967837360 @default.
• W2040390621 cites W1970370314 @default.
• W2040390621 cites W1975122757 @default.
• W2040390621 cites W1975175174 @default.
• W2040390621 cites W1979864502 @default.
• W2040390621 cites W1986367921 @default.
• W2040390621 cites W1990633912 @default.
• W2040390621 cites W1993796162 @default.
• W2040390621 cites W1994135330 @default.
• W2040390621 cites W2003042213 @default.
• W2040390621 cites W2005384485 @default.
• W2040390621 cites W2010539647 @default.
• W2040390621 cites W2016151173 @default.
• W2040390621 cites W2024671767 @default.
• W2040390621 cites W2026070855 @default.
• W2040390621 cites W2030226964 @default.
• W2040390621 cites W2030374993 @default.
• W2040390621 cites W2037123248 @default.
• W2040390621 cites W2044193604 @default.
• W2040390621 cites W2047487027 @default.
• W2040390621 cites W2050520863 @default.
• W2040390621 cites W2051133749 @default.
• W2040390621 cites W2051490011 @default.
• W2040390621 cites W2059421179 @default.
• W2040390621 cites W2064270760 @default.
• W2040390621 cites W2064284773 @default.
• W2040390621 cites W2066926626 @default.
• W2040390621 cites W2072774060 @default.
• W2040390621 cites W2075517709 @default.
• W2040390621 cites W2087166273 @default.
• W2040390621 cites W2089160138 @default.
• W2040390621 cites W2094891876 @default.
• W2040390621 cites W2100727504 @default.
• W2040390621 cites W2111875633 @default.
• W2040390621 cites W2115444809 @default.
• W2040390621 cites W2117722803 @default.
• W2040390621 cites W2119425355 @default.
• W2040390621 cites W2154296350 @default.
• W2040390621 cites W2160439166 @default.
• W2040390621 cites W2167107393 @default.
• W2040390621 cites W225880338 @default.
• W2040390621 cites W2329518950 @default.
• W2040390621 cites W2338082592 @default.
• W2040390621 cites W4232534952 @default.
• W2040390621 doi "https://doi.org/10.1016/j.ejps.2009.05.002" @default.
• W2040390621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19442721" @default.
• W2040390621 hasPublicationYear "2009" @default.
• W2040390621 type Work @default.
• W2040390621 sameAs 2040390621 @default.
• W2040390621 citedByCount "17" @default.
• W2040390621 countsByYear W20403906212012 @default.
• W2040390621 countsByYear W20403906212013 @default.
• W2040390621 countsByYear W20403906212014 @default.
• W2040390621 countsByYear W20403906212016 @default.
• W2040390621 countsByYear W20403906212017 @default.
• W2040390621 crossrefType "journal-article" @default.
• W2040390621 hasAuthorship W2040390621A5000547718 @default.
• W2040390621 hasAuthorship W2040390621A5029219877 @default.
• W2040390621 hasAuthorship W2040390621A5070452365 @default.
• W2040390621 hasConcept C111337013 @default.
• W2040390621 hasConcept C121332964 @default.
• W2040390621 hasConcept C147483822 @default.
• W2040390621 hasConcept C148761745 @default.
• W2040390621 hasConcept C162324750 @default.
• W2040390621 hasConcept C185544564 @default.
• W2040390621 hasConcept C185592680 @default.
• W2040390621 hasConcept C203014093 @default.
• W2040390621 hasConcept C2779026604 @default.
• W2040390621 hasConcept C2983132609 @default.
• W2040390621 hasConcept C3017806408 @default.
• W2040390621 hasConcept C536366893 @default.
• W2040390621 hasConcept C556758197 @default.
• W2040390621 hasConcept C86803240 @default.
• W2040390621 hasConcept C89423630 @default.
• W2040390621 hasConceptScore W2040390621C111337013 @default.
• W2040390621 hasConceptScore W2040390621C121332964 @default.
• W2040390621 hasConceptScore W2040390621C147483822 @default.
• W2040390621 hasConceptScore W2040390621C148761745 @default.
• W2040390621 hasConceptScore W2040390621C162324750 @default.
• W2040390621 hasConceptScore W2040390621C185544564 @default.
• W2040390621 hasConceptScore W2040390621C185592680 @default.
• W2040390621 hasConceptScore W2040390621C203014093 @default.
• W2040390621 hasConceptScore W2040390621C2779026604 @default.
• W2040390621 hasConceptScore W2040390621C2983132609 @default.
• W2040390621 hasConceptScore W2040390621C3017806408 @default.
• W2040390621 hasConceptScore W2040390621C536366893 @default.

• next