FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040392331> ?p ?o ?g. }

• W2040392331 endingPage "1102" @default.
• W2040392331 startingPage "1092" @default.
• W2040392331 abstract "Malignant peripheral nerve sheath tumors (MPNST) are the most aggressive cancers associated with neurofibromatosis type 1 (NF1). Here we report a practical and reproducible model of intraneural NF1 MPNST, by orthotopic xenograft of an immortal human NF1 tumor-derived Schwann cell line into the sciatic nerves of female scid mice. Intraneural injection of the cell line sNF96.2 consistently produced MPNST-like tumors that were highly cellular and showed extensive intraneural growth. These xenografts had a high proliferative index, were angiogenic, had significant mast cell infiltration and rapidly dominated the host nerve. The histopathology of engrafted intraneural tumors was consistent with that of human NF1 MPNST. Xenograft tumors were readily examined by magnetic resonance imaging, which also was used to assess tumor vascularity. In addition, the intraneural proliferation of sNF96.2 cell tumors was decreased in ovariectomized mice, while replacement of estrogen or progesterone restored tumor cell proliferation. This suggests a potential role for steroid hormones in supporting tumor cell growth of this MPNST cell line in vivo. The controlled orthotopic implantation of sNF96.2 cells provides for the precise initiation of intraneural MPNST-like tumors in a model system suitable for therapeutic interventions, including inhibitors of angiogenesis and further study of steroid hormone effects on tumor cell growth." @default.
• W2040392331 created "2016-06-24" @default.
• W2040392331 creator A5001227908 @default.
• W2040392331 creator A5015258714 @default.
• W2040392331 creator A5032940705 @default.
• W2040392331 creator A5035315683 @default.
• W2040392331 creator A5042141904 @default.
• W2040392331 creator A5049085920 @default.
• W2040392331 creator A5049632912 @default.
• W2040392331 creator A5062361695 @default.
• W2040392331 creator A5078828859 @default.
• W2040392331 creator A5089253041 @default.
• W2040392331 date "2007-11-01" @default.
• W2040392331 modified "2023-10-13" @default.
• W2040392331 title "An orthotopic xenograft model of intraneural NF1 MPNST suggests a potential association between steroid hormones and tumor cell proliferation" @default.
• W2040392331 cites W1499621409 @default.
• W2040392331 cites W1569960499 @default.
• W2040392331 cites W1952508659 @default.
• W2040392331 cites W1963509038 @default.
• W2040392331 cites W1975653248 @default.
• W2040392331 cites W1978073516 @default.
• W2040392331 cites W1979154683 @default.
• W2040392331 cites W1979856883 @default.
• W2040392331 cites W1981950973 @default.
• W2040392331 cites W1982646874 @default.
• W2040392331 cites W1985601479 @default.
• W2040392331 cites W1999693030 @default.
• W2040392331 cites W2000690172 @default.
• W2040392331 cites W2012897956 @default.
• W2040392331 cites W2017444651 @default.
• W2040392331 cites W2019578259 @default.
• W2040392331 cites W2032346608 @default.
• W2040392331 cites W2038611597 @default.
• W2040392331 cites W2040298237 @default.
• W2040392331 cites W2041480649 @default.
• W2040392331 cites W2042098439 @default.
• W2040392331 cites W2047337667 @default.
• W2040392331 cites W2048140690 @default.
• W2040392331 cites W2050503537 @default.
• W2040392331 cites W2051292894 @default.
• W2040392331 cites W2053926251 @default.
• W2040392331 cites W2054674800 @default.
• W2040392331 cites W2055729102 @default.
• W2040392331 cites W2056433983 @default.
• W2040392331 cites W2058181961 @default.
• W2040392331 cites W2058306120 @default.
• W2040392331 cites W2061350341 @default.
• W2040392331 cites W2063057728 @default.
• W2040392331 cites W2075776423 @default.
• W2040392331 cites W2094736530 @default.
• W2040392331 cites W2122184474 @default.
• W2040392331 cites W2131291777 @default.
• W2040392331 cites W2137036286 @default.
• W2040392331 cites W2137082791 @default.
• W2040392331 cites W2145481360 @default.
• W2040392331 cites W2147314281 @default.
• W2040392331 cites W2149309119 @default.
• W2040392331 cites W2159562139 @default.
• W2040392331 cites W2160584364 @default.
• W2040392331 cites W2167636795 @default.
• W2040392331 cites W4243204060 @default.
• W2040392331 cites W4248770360 @default.
• W2040392331 cites W4250428608 @default.
• W2040392331 cites W4255825445 @default.
• W2040392331 doi "https://doi.org/10.1038/labinvest.3700675" @default.
• W2040392331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17876295" @default.
• W2040392331 hasPublicationYear "2007" @default.
• W2040392331 type Work @default.
• W2040392331 sameAs 2040392331 @default.
• W2040392331 citedByCount "31" @default.
• W2040392331 countsByYear W20403923312012 @default.
• W2040392331 countsByYear W20403923312014 @default.
• W2040392331 countsByYear W20403923312015 @default.
• W2040392331 countsByYear W20403923312016 @default.
• W2040392331 countsByYear W20403923312017 @default.
• W2040392331 countsByYear W20403923312018 @default.
• W2040392331 countsByYear W20403923312019 @default.
• W2040392331 countsByYear W20403923312020 @default.
• W2040392331 countsByYear W20403923312021 @default.
• W2040392331 countsByYear W20403923312022 @default.
• W2040392331 countsByYear W20403923312023 @default.
• W2040392331 crossrefType "journal-article" @default.
• W2040392331 hasAuthorship W2040392331A5001227908 @default.
• W2040392331 hasAuthorship W2040392331A5015258714 @default.
• W2040392331 hasAuthorship W2040392331A5032940705 @default.
• W2040392331 hasAuthorship W2040392331A5035315683 @default.
• W2040392331 hasAuthorship W2040392331A5042141904 @default.
• W2040392331 hasAuthorship W2040392331A5049085920 @default.
• W2040392331 hasAuthorship W2040392331A5049632912 @default.
• W2040392331 hasAuthorship W2040392331A5062361695 @default.
• W2040392331 hasAuthorship W2040392331A5078828859 @default.
• W2040392331 hasAuthorship W2040392331A5089253041 @default.
• W2040392331 hasBestOaLocation W20403923311 @default.
• W2040392331 hasConcept C142724271 @default.
• W2040392331 hasConcept C170932241 @default.
• W2040392331 hasConcept C2778173781 @default.
• W2040392331 hasConcept C2778984943 @default.
• W2040392331 hasConcept C2780394083 @default.

• next