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- W2040393622 abstract "Objective: The aims of this work are to enhance the in vitro skin permeation of Houttuynia cordata (water-soluble extract of H. cordata; HCWSE) and to boost the efficacy of HCWSE against atopic dermatitis (AD) – like skin lesion in hairless mice using lipid nano-carriers (liposome and cubosome).Methods: HCWSE was obtained by a hot water extraction. Monoolein cubosomal suspension containing HCWSE and egg phosphatidylcholine liposomal suspension containing the same was prepared by a sonication and a film hydration method, respectively.Results: The lipid nano-carriers, especially cubosome, enhanced the in vitro skin permeation of HCWSE. The inhibitory effects of HCWSE-containing lipid carrier suspensions on the development of 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD-like skin lesion in hairless mice were investigated by observing appearance of skin surface, serum immunoglobulin E (IgE) level and cytokine expression. HCWSE-containing preparations suppressed IgE production and interleukin 4 expression, whereas they promoted interferon gamma expression. The order of lymphocyte (B-cell, Th1 cell and Th2 cell) modulating effect was HCWSE-containing cubosomal suspension > HCWSE-containing liposomal suspension > HCWSE solution in phosphate buffered saline, indicating that the cubosomal suspension, among the preparations, was the most efficacious in inhibiting the development of DNCB-induced AD-like skin lesion.Conclusion: It is believed that the cubosomal suspension containing HCWSE would be an efficacious preparation for the treatment of AD." @default.
- W2040393622 created "2016-06-24" @default.
- W2040393622 creator A5028845989 @default.
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- W2040393622 date "2013-07-25" @default.
- W2040393622 modified "2023-09-23" @default.
- W2040393622 title "<i>In vitro</i>skin permeation and anti-atopic efficacy of lipid nanocarriers containing water soluble extracts of<i>Houttuynia cordata</i>" @default.
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- W2040393622 doi "https://doi.org/10.3109/03639045.2013.819883" @default.
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