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- W2040394799 abstract "Serotonin (5-hydroxytryptamine, 5-HT) may play an important role in the pathogenesis of schizophrenia. Previous studies suggested that the efficacy of atypical neuroleptic drugs (e.g., risperidone and clozapine) on negative symptoms may be related to the 5-HT2a receptor. Although association studies between MspI polymorphism (T102C) and the 5-HT2a receptor gene and schizophrenia have been reported, their results are still controversial. The aim of this study was to examine the association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia as well as the association between the polymorphism and negative symptoms in a Japanese population (106 patients with schizophrenia and 109 healthy controls). No significant positive associations were observed. Our results suggest that the 5-HT2a receptor gene is not involved in the pathogenesis of schizophrenia or negative symptoms." @default.
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- W2040394799 date "1998-01-01" @default.
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- W2040394799 title "Negative Association between T102C Polymorphism of the 5-HT<sub>2a</sub> Receptor Gene and Schizophrenia in Japan" @default.
- W2040394799 cites W1981124675 @default.
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- W2040394799 doi "https://doi.org/10.1159/000022803" @default.
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