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• W2040394984 abstract "Purpose To identify laboratory predictors of a positive temporal artery biopsy. Design Cross-sectional study using retrospective electronic data base review. Participants There were 3001 patients who had a temporal artery biopsy. Methods The electronic database of a large health maintenance organization was searched for all patients who had a temporal artery biopsy performed from 1997 to 2006. Main Outcome Measures Odds ratios for erythrocyte sedimentation rate, C-reactive protein (CRP), and platelet count values associated with a positive temporal artery biopsy. Results Four hundred fifty-nine cases of biopsy-proven giant cell arteritis were identified. The odds of a positive biopsy were 1.5 times greater with an erythrocyte sedimentation rate of 47 to 107 mm/hr, 5.3 times greater with a CRP >2.45 mg/dL, and 4.2 times greater with platelets >400 000/μL. Conclusions In this largest population-based giant cell arteritis study in the United States to date, we reaffirm Hayreh's finding of the significance of a CRP level >2.45 mg/dL in predicting a positive biopsy. Our findings support the literature suggesting that CRP and thrombocytosis may be stronger predictors of positive biopsy than erythrocyte sedimentation rate. Financial Disclosure(s) The authors have no proprietary or commercial interest in any of the materials discussed in this article. To identify laboratory predictors of a positive temporal artery biopsy. Cross-sectional study using retrospective electronic data base review. There were 3001 patients who had a temporal artery biopsy. The electronic database of a large health maintenance organization was searched for all patients who had a temporal artery biopsy performed from 1997 to 2006. Odds ratios for erythrocyte sedimentation rate, C-reactive protein (CRP), and platelet count values associated with a positive temporal artery biopsy. Four hundred fifty-nine cases of biopsy-proven giant cell arteritis were identified. The odds of a positive biopsy were 1.5 times greater with an erythrocyte sedimentation rate of 47 to 107 mm/hr, 5.3 times greater with a CRP >2.45 mg/dL, and 4.2 times greater with platelets >400 000/μL. In this largest population-based giant cell arteritis study in the United States to date, we reaffirm Hayreh's finding of the significance of a CRP level >2.45 mg/dL in predicting a positive biopsy. Our findings support the literature suggesting that CRP and thrombocytosis may be stronger predictors of positive biopsy than erythrocyte sedimentation rate." @default.
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• W2040394984 date "2011-06-01" @default.
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• W2040394984 title "Giant Cell Arteritis: Laboratory Predictors of a Positive Temporal Artery Biopsy" @default.
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• W2040394984 doi "https://doi.org/10.1016/j.ophtha.2010.10.002" @default.
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