FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040395090> ?p ?o ?g. }

• W2040395090 endingPage "27" @default.
• W2040395090 startingPage "21" @default.
• W2040395090 abstract "Chronic hepatitis C is often associated with liver iron overload, which may affect the long-term prognosis and the response to antiviral treatment. The occurrence of hemochromatosis (HFE) mutations were studied to determine whether may contribute to the liver iron overload of chronic hepatitis C patients. The prevalence of two HFE mutations (C282Y and H63D) in 120 chronic hepatitis C patients was determined and the findings were correlated with clinical, histological and virological features. Hepatic iron was determined semiquantitatively by a histochemical hepatic iron index, defined as the ratio of a histochemical staining score to the patient's age, after correction for heterogeneous lobular iron distribution. Serum hepatitis C virus (HCV) RNA was measured by bDNA assay and typed by restriction fragment length polymorphism. Liver HCV RNA was measured by a semi-quantitative strand-specific reverse transcription-polymerase chain reaction (RT-PCR). Excess liver iron was stained in the liver of 36 patients (30%). Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients. However, siderotic patients were older (P = 0.015), more frequently males (P = 0.02), less frequently infected with HCV genotype 3 (P = 0.037) and had a higher liver fibrosis score (P = 0.008). The liver iron content did not correlate with the serum or liver HCV RNA titers. Ten of the 36 patients with liver siderosis had neither a history of excess alcohol intake, multiple transfusions, or HFE mutations. In conclusion, the pathogenesis of the liver iron overload in chronic hepatitis C patients cannot be fully explained by the occurrence of HFE mutations. The exact mechanism of iron accumulation in these patients therefore remains unexplained. J. Med. Virol. 60:21–27, 2000. © 2000 Wiley-Liss, Inc." @default.
• W2040395090 created "2016-06-24" @default.
• W2040395090 creator A5004642302 @default.
• W2040395090 creator A5021900099 @default.
• W2040395090 creator A5026722725 @default.
• W2040395090 creator A5029222851 @default.
• W2040395090 creator A5045075044 @default.
• W2040395090 creator A5048389089 @default.
• W2040395090 creator A5049367748 @default.
• W2040395090 creator A5073307450 @default.
• W2040395090 creator A5078008109 @default.
• W2040395090 creator A5091217324 @default.
• W2040395090 date "2000-01-01" @default.
• W2040395090 modified "2023-10-18" @default.
• W2040395090 title "Hemochromatosis gene mutations in chronic hepatitis C patients with and without liver siderosis" @default.
• W2040395090 cites W1480007741 @default.
• W2040395090 cites W1848552725 @default.
• W2040395090 cites W1950035658 @default.
• W2040395090 cites W1973334349 @default.
• W2040395090 cites W1975523149 @default.
• W2040395090 cites W1975995361 @default.
• W2040395090 cites W1978050002 @default.
• W2040395090 cites W1989145216 @default.
• W2040395090 cites W1992908452 @default.
• W2040395090 cites W1999956739 @default.
• W2040395090 cites W2002605005 @default.
• W2040395090 cites W2007653659 @default.
• W2040395090 cites W2009301192 @default.
• W2040395090 cites W2016695765 @default.
• W2040395090 cites W2022419825 @default.
• W2040395090 cites W2024522228 @default.
• W2040395090 cites W2026270647 @default.
• W2040395090 cites W2026543492 @default.
• W2040395090 cites W2032755864 @default.
• W2040395090 cites W2033948801 @default.
• W2040395090 cites W2044886244 @default.
• W2040395090 cites W2045839792 @default.
• W2040395090 cites W2048313733 @default.
• W2040395090 cites W2056588489 @default.
• W2040395090 cites W2062225736 @default.
• W2040395090 cites W2063072742 @default.
• W2040395090 cites W2063909729 @default.
• W2040395090 cites W2070141763 @default.
• W2040395090 cites W2082183799 @default.
• W2040395090 cites W2085723845 @default.
• W2040395090 cites W2091464815 @default.
• W2040395090 cites W2093202187 @default.
• W2040395090 cites W2107103400 @default.
• W2040395090 cites W2110118982 @default.
• W2040395090 cites W2113550355 @default.
• W2040395090 cites W2114030946 @default.
• W2040395090 cites W2137056224 @default.
• W2040395090 cites W2137880935 @default.
• W2040395090 cites W2152805462 @default.
• W2040395090 cites W2159954692 @default.
• W2040395090 cites W2162310882 @default.
• W2040395090 cites W2164035951 @default.
• W2040395090 cites W2320925065 @default.
• W2040395090 cites W2415133079 @default.
• W2040395090 cites W2470599311 @default.
• W2040395090 doi "https://doi.org/10.1002/(sici)1096-9071(200001)60:1<21::aid-jmv4>3.0.co;2-f" @default.
• W2040395090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10568758" @default.
• W2040395090 hasPublicationYear "2000" @default.
• W2040395090 type Work @default.
• W2040395090 sameAs 2040395090 @default.
• W2040395090 citedByCount "57" @default.
• W2040395090 countsByYear W20403950902012 @default.
• W2040395090 countsByYear W20403950902015 @default.
• W2040395090 countsByYear W20403950902017 @default.
• W2040395090 countsByYear W20403950902019 @default.
• W2040395090 countsByYear W20403950902021 @default.
• W2040395090 crossrefType "journal-article" @default.
• W2040395090 hasAuthorship W2040395090A5004642302 @default.
• W2040395090 hasAuthorship W2040395090A5021900099 @default.
• W2040395090 hasAuthorship W2040395090A5026722725 @default.
• W2040395090 hasAuthorship W2040395090A5029222851 @default.
• W2040395090 hasAuthorship W2040395090A5045075044 @default.
• W2040395090 hasAuthorship W2040395090A5048389089 @default.
• W2040395090 hasAuthorship W2040395090A5049367748 @default.
• W2040395090 hasAuthorship W2040395090A5073307450 @default.
• W2040395090 hasAuthorship W2040395090A5078008109 @default.
• W2040395090 hasAuthorship W2040395090A5091217324 @default.
• W2040395090 hasConcept C126322002 @default.
• W2040395090 hasConcept C142724271 @default.
• W2040395090 hasConcept C159047783 @default.
• W2040395090 hasConcept C2522874641 @default.
• W2040395090 hasConcept C2776408679 @default.
• W2040395090 hasConcept C2776455275 @default.
• W2040395090 hasConcept C2776590208 @default.
• W2040395090 hasConcept C2777075537 @default.
• W2040395090 hasConcept C2780559512 @default.
• W2040395090 hasConcept C2780883591 @default.
• W2040395090 hasConcept C3018783601 @default.
• W2040395090 hasConcept C71924100 @default.
• W2040395090 hasConcept C90924648 @default.
• W2040395090 hasConceptScore W2040395090C126322002 @default.
• W2040395090 hasConceptScore W2040395090C142724271 @default.
• W2040395090 hasConceptScore W2040395090C159047783 @default.

• next