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- W2040396563 abstract "Abstract In order to investigate the relationship between atherosclerosis in diabetes mellitus and the factor VIII complex, diabetic patients were studied who had three progressive levels of vascular diseases: 1) juvenile-onset diabetics without retinopathy, 2) juvenile-onset diabetics with proliferative retinopathy, and 3) maturity-onset diabetics with atherosclerosis. They were compared to normal controls and to non-diabetics with atherosclerosis. Plasma levels of VIII-related antigen (VIII R:Ag), VIII coagulant (VIII:C), and von Willebrand/Ristocetin cofactor (VIII:Rcof), fibrinogen, fibrinolytic activity, cholesterol, triglyceride, and hemoglobin (Hgb) A 1C levels were measured. Atherosclerotics with and without diabetes had greater VIII:C, VIII R:Ag, and VIII:Rcof than controls. The juvenile-onset diabetics had elevated VIII:C and VIII R:Ag but normal levels of VIII:Rcof compared to controls. Fibrinolytic activity was higher in diabetics than the other groups. Cholesterol and triglyceride levels were elevated in diabetics with retinopathy as well as in atherosclerotics with and without diabetes. Fibrinogen was elevated only in the atherosclerotic patients. Hgb A 1C was elevated in all diabetic groups. These findings suggest that elevations in VIII:C, VIII R:Ag, and VIII:Rcof are related as much to the atherosclerosis as to the diabetes. Changes in the factor VIII complex may appear at a younger age in patients with diabetes mellitus." @default.
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- W2040396563 date "1980-09-01" @default.
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- W2040396563 title "Changes of fibrinolysis and factor VIII coagulant, antigen, and ristocetin cofactor in diabetes mellitus and atherosclerosis" @default.
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- W2040396563 doi "https://doi.org/10.1016/0049-3848(80)90011-0" @default.
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