FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040397939> ?p ?o ?g. }

• W2040397939 endingPage "489" @default.
• W2040397939 startingPage "485" @default.
• W2040397939 abstract "A new crystal structure of activin in complex with the extracellular domain of its type II receptor (ActRIIb-ECD) shows that the ligand exhibits an unexpected flexibility. The motion in the activin dimer disrupts its type I receptor interface, which may account for the disparity in its affinity for type I versus type II receptors. We have measured the affinities of activin and its antagonist inhibin for ActRIIb-ECD and found that the affinity of the 2-fold symmetric homodimer activin for ActRIIb-ECD depends on the availability of two spatially coupled ActRIIb-ECD molecules, whereas the affinity of the heterodimer inhibin does not. Our results indicate that activin's affinity for its two receptor types is greatly influenced by their membrane-restricted setting. We propose that activin affinity is modulated by the ligand flexibility and that cooperativity is achieved by binding to two ActRII chains that immobilize activin in a type I binding-competent orientation." @default.
• W2040397939 created "2016-06-24" @default.
• W2040397939 creator A5005181606 @default.
• W2040397939 creator A5011793639 @default.
• W2040397939 creator A5033348306 @default.
• W2040397939 creator A5046776637 @default.
• W2040397939 creator A5047503803 @default.
• W2040397939 creator A5086201229 @default.
• W2040397939 date "2004-08-01" @default.
• W2040397939 modified "2023-10-09" @default.
• W2040397939 title "A Flexible Activin Explains the Membrane-Dependent Cooperative Assembly of TGF-β Family Receptors" @default.
• W2040397939 cites W1494055834 @default.
• W2040397939 cites W1863348815 @default.
• W2040397939 cites W1881580349 @default.
• W2040397939 cites W1968385313 @default.
• W2040397939 cites W1973403657 @default.
• W2040397939 cites W1998488983 @default.
• W2040397939 cites W2004391976 @default.
• W2040397939 cites W2007539627 @default.
• W2040397939 cites W2013083986 @default.
• W2040397939 cites W2024057452 @default.
• W2040397939 cites W2025864476 @default.
• W2040397939 cites W2030205108 @default.
• W2040397939 cites W2033488181 @default.
• W2040397939 cites W2036088572 @default.
• W2040397939 cites W2036509369 @default.
• W2040397939 cites W2045869760 @default.
• W2040397939 cites W2049586866 @default.
• W2040397939 cites W2051465511 @default.
• W2040397939 cites W2062656302 @default.
• W2040397939 cites W2068857057 @default.
• W2040397939 cites W2070921472 @default.
• W2040397939 cites W2071251725 @default.
• W2040397939 cites W2103031848 @default.
• W2040397939 cites W2103530688 @default.
• W2040397939 cites W2115806010 @default.
• W2040397939 cites W2154568166 @default.
• W2040397939 cites W2155539632 @default.
• W2040397939 doi "https://doi.org/10.1016/j.molcel.2004.07.011" @default.
• W2040397939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15304227" @default.
• W2040397939 hasPublicationYear "2004" @default.
• W2040397939 type Work @default.
• W2040397939 sameAs 2040397939 @default.
• W2040397939 citedByCount "121" @default.
• W2040397939 countsByYear W20403979392012 @default.
• W2040397939 countsByYear W20403979392013 @default.
• W2040397939 countsByYear W20403979392014 @default.
• W2040397939 countsByYear W20403979392015 @default.
• W2040397939 countsByYear W20403979392016 @default.
• W2040397939 countsByYear W20403979392017 @default.
• W2040397939 countsByYear W20403979392018 @default.
• W2040397939 countsByYear W20403979392019 @default.
• W2040397939 countsByYear W20403979392020 @default.
• W2040397939 countsByYear W20403979392021 @default.
• W2040397939 countsByYear W20403979392022 @default.
• W2040397939 countsByYear W20403979392023 @default.
• W2040397939 crossrefType "journal-article" @default.
• W2040397939 hasAuthorship W2040397939A5005181606 @default.
• W2040397939 hasAuthorship W2040397939A5011793639 @default.
• W2040397939 hasAuthorship W2040397939A5033348306 @default.
• W2040397939 hasAuthorship W2040397939A5046776637 @default.
• W2040397939 hasAuthorship W2040397939A5047503803 @default.
• W2040397939 hasAuthorship W2040397939A5086201229 @default.
• W2040397939 hasBestOaLocation W20403979391 @default.
• W2040397939 hasConcept C111001777 @default.
• W2040397939 hasConcept C116569031 @default.
• W2040397939 hasConcept C12554922 @default.
• W2040397939 hasConcept C166014724 @default.
• W2040397939 hasConcept C170493617 @default.
• W2040397939 hasConcept C22517002 @default.
• W2040397939 hasConcept C2778649528 @default.
• W2040397939 hasConcept C38643226 @default.
• W2040397939 hasConcept C55493867 @default.
• W2040397939 hasConcept C86803240 @default.
• W2040397939 hasConcept C95444343 @default.
• W2040397939 hasConceptScore W2040397939C111001777 @default.
• W2040397939 hasConceptScore W2040397939C116569031 @default.
• W2040397939 hasConceptScore W2040397939C12554922 @default.
• W2040397939 hasConceptScore W2040397939C166014724 @default.
• W2040397939 hasConceptScore W2040397939C170493617 @default.
• W2040397939 hasConceptScore W2040397939C22517002 @default.
• W2040397939 hasConceptScore W2040397939C2778649528 @default.
• W2040397939 hasConceptScore W2040397939C38643226 @default.
• W2040397939 hasConceptScore W2040397939C55493867 @default.
• W2040397939 hasConceptScore W2040397939C86803240 @default.
• W2040397939 hasConceptScore W2040397939C95444343 @default.
• W2040397939 hasIssue "3" @default.
• W2040397939 hasLocation W20403979391 @default.
• W2040397939 hasLocation W20403979392 @default.
• W2040397939 hasOpenAccess W2040397939 @default.
• W2040397939 hasPrimaryLocation W20403979391 @default.
• W2040397939 hasRelatedWork W1698471171 @default.
• W2040397939 hasRelatedWork W1977151351 @default.
• W2040397939 hasRelatedWork W1978409052 @default.
• W2040397939 hasRelatedWork W1987201164 @default.
• W2040397939 hasRelatedWork W2036509369 @default.
• W2040397939 hasRelatedWork W2061778966 @default.
• W2040397939 hasRelatedWork W2148402618 @default.

• next