FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040398886> ?p ?o ?g. }

• W2040398886 endingPage "480" @default.
• W2040398886 startingPage "474" @default.
• W2040398886 abstract "Mammalian sterile 20-kinase 1 (Mst1), a member of the sterile-20 family protein kinase, plays an important role in the induction of apoptosis. However, little is know about the physiological activator of Mst1 and the role of Mst1 in endothelial cells (ECs). We examined whether Mst1 is involved in the tumor necrosis factor (TNF)-α-induced apoptosis of ECs. Western blot analysis revealed that TNF-α induced activation of caspase 3 and Mst1 in a time- and dose-dependent manner. TNF-α-induced Mst1 activation is almost completely prevented by pretreatment with Z-DEVD-FMK, a caspase 3 inhibitor. Nuclear staining with Hoechst 33258 and fluorescence-activated cell sorting of propidium iodide-stained cells showed that TNF-α induced apoptosis of EC. Diphenyleneiodonium, an inhibitor of NADPH oxidase, and N-acetylcysteine, a potent antioxidant, also inhibited TNF-α-induced activation of Mst1 and caspase 3, as well as apoptosis. Knockdown of Mst1 expression by short interfering RNA attenuated TNF-α-induced apoptosis but not cleavage of caspase 3. These results suggest that Mst1 plays an important role in the induction of TNF-α-induced apoptosis of EC. However, positive feedback mechanism between Mst1 and caspase 3, which was shown in the previous studies, was not observed. Inhibition of Mst1 function may be beneficial for maintaining the endothelial integrity and inhibition of atherogenesis." @default.
• W2040398886 created "2016-06-24" @default.
• W2040398886 creator A5001057221 @default.
• W2040398886 creator A5007483946 @default.
• W2040398886 creator A5011738480 @default.
• W2040398886 creator A5029771818 @default.
• W2040398886 creator A5057771677 @default.
• W2040398886 creator A5080191320 @default.
• W2040398886 creator A5081318837 @default.
• W2040398886 creator A5091471046 @default.
• W2040398886 date "2008-03-01" @default.
• W2040398886 modified "2023-09-26" @default.
• W2040398886 title "Involvement of Mst1 in tumor necrosis factor-α-induced apoptosis of endothelial cells" @default.
• W2040398886 cites W17992636 @default.
• W2040398886 cites W1972138202 @default.
• W2040398886 cites W1974762803 @default.
• W2040398886 cites W1982584793 @default.
• W2040398886 cites W2006691286 @default.
• W2040398886 cites W2009500414 @default.
• W2040398886 cites W2019978702 @default.
• W2040398886 cites W2021693564 @default.
• W2040398886 cites W2026803942 @default.
• W2040398886 cites W2030078522 @default.
• W2040398886 cites W2032806953 @default.
• W2040398886 cites W2032853143 @default.
• W2040398886 cites W2043155515 @default.
• W2040398886 cites W2085215980 @default.
• W2040398886 cites W2102181113 @default.
• W2040398886 cites W2105959408 @default.
• W2040398886 cites W2106319388 @default.
• W2040398886 cites W2114111268 @default.
• W2040398886 cites W2119031668 @default.
• W2040398886 cites W2122486350 @default.
• W2040398886 cites W2128786825 @default.
• W2040398886 cites W2130682733 @default.
• W2040398886 cites W2141443485 @default.
• W2040398886 cites W2144903567 @default.
• W2040398886 cites W2147553897 @default.
• W2040398886 cites W2153141596 @default.
• W2040398886 cites W2155760431 @default.
• W2040398886 cites W2159087408 @default.
• W2040398886 cites W2162434225 @default.
• W2040398886 cites W2167096785 @default.
• W2040398886 cites W2324841714 @default.
• W2040398886 cites W3196550503 @default.
• W2040398886 doi "https://doi.org/10.1016/j.bbrc.2007.12.173" @default.
• W2040398886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18182160" @default.
• W2040398886 hasPublicationYear "2008" @default.
• W2040398886 type Work @default.
• W2040398886 sameAs 2040398886 @default.
• W2040398886 citedByCount "2" @default.
• W2040398886 countsByYear W20403988862012 @default.
• W2040398886 countsByYear W20403988862019 @default.
• W2040398886 crossrefType "journal-article" @default.
• W2040398886 hasAuthorship W2040398886A5001057221 @default.
• W2040398886 hasAuthorship W2040398886A5007483946 @default.
• W2040398886 hasAuthorship W2040398886A5011738480 @default.
• W2040398886 hasAuthorship W2040398886A5029771818 @default.
• W2040398886 hasAuthorship W2040398886A5057771677 @default.
• W2040398886 hasAuthorship W2040398886A5080191320 @default.
• W2040398886 hasAuthorship W2040398886A5081318837 @default.
• W2040398886 hasAuthorship W2040398886A5091471046 @default.
• W2040398886 hasConcept C12519072 @default.
• W2040398886 hasConcept C153911025 @default.
• W2040398886 hasConcept C17991360 @default.
• W2040398886 hasConcept C184235292 @default.
• W2040398886 hasConcept C185592680 @default.
• W2040398886 hasConcept C190283241 @default.
• W2040398886 hasConcept C203014093 @default.
• W2040398886 hasConcept C22615655 @default.
• W2040398886 hasConcept C2775934118 @default.
• W2040398886 hasConcept C31573885 @default.
• W2040398886 hasConcept C502942594 @default.
• W2040398886 hasConcept C54009773 @default.
• W2040398886 hasConcept C54355233 @default.
• W2040398886 hasConcept C55493867 @default.
• W2040398886 hasConcept C81885089 @default.
• W2040398886 hasConcept C86803240 @default.
• W2040398886 hasConcept C95444343 @default.
• W2040398886 hasConceptScore W2040398886C12519072 @default.
• W2040398886 hasConceptScore W2040398886C153911025 @default.
• W2040398886 hasConceptScore W2040398886C17991360 @default.
• W2040398886 hasConceptScore W2040398886C184235292 @default.
• W2040398886 hasConceptScore W2040398886C185592680 @default.
• W2040398886 hasConceptScore W2040398886C190283241 @default.
• W2040398886 hasConceptScore W2040398886C203014093 @default.
• W2040398886 hasConceptScore W2040398886C22615655 @default.
• W2040398886 hasConceptScore W2040398886C2775934118 @default.
• W2040398886 hasConceptScore W2040398886C31573885 @default.
• W2040398886 hasConceptScore W2040398886C502942594 @default.
• W2040398886 hasConceptScore W2040398886C54009773 @default.
• W2040398886 hasConceptScore W2040398886C54355233 @default.
• W2040398886 hasConceptScore W2040398886C55493867 @default.
• W2040398886 hasConceptScore W2040398886C81885089 @default.
• W2040398886 hasConceptScore W2040398886C86803240 @default.
• W2040398886 hasConceptScore W2040398886C95444343 @default.
• W2040398886 hasFunder F4320320912 @default.
• W2040398886 hasIssue "2" @default.

• next