FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040403266> ?p ?o ?g. }

• W2040403266 endingPage "1033" @default.
• W2040403266 startingPage "1022" @default.
• W2040403266 abstract "The T-box family of transcription factors has been shown to have major impact on human development and disease. In animal studies Tbx20 is essential for the development of the atrioventricular channel, the outflow tract and valves, suggesting its potential causative role for the development of Tetralogy of Fallot (TOF) in humans. In the presented study, we analyzed TBX20 in cardiac biopsies derived from patients with TOF, ventricular septal defects (VSDs) and normal hearts. Mutation analysis did not reveal any disease causing sequence variation, however, TBX20 is significantly upregulated in tissue samples of patients with TOF, but not VSD. In depth analysis of TBX20 transcripts lead to the identification of two new exons 3′ to the known TBX20 message resembling the mouse variant Tbx20a, as well as an extended 5′UTR. Functional analysis of the human TBX20 promoter revealed a 100 bp region that contains strong activating elements. Within this core promoter region we recognized functional binding sites for TFAP2 transcription factors and identified TFAP2 as repressors of the TBX20 gene in vitro and in vivo. Moreover, decreased TFAP2C levels in cardiac biopsies of TOF patients underline the biological significance of the pathway described. In summary, we provide first insights into the regulation of TBX20 and show its potential for human congenital heart diseases. J. Cell. Biochem. 104: 1022–1033, 2008. © 2008 Wiley-Liss, Inc." @default.
• W2040403266 created "2016-06-24" @default.
• W2040403266 creator A5001062617 @default.
• W2040403266 creator A5007168347 @default.
• W2040403266 creator A5015618150 @default.
• W2040403266 creator A5035857958 @default.
• W2040403266 creator A5062147292 @default.
• W2040403266 creator A5079184552 @default.
• W2040403266 creator A5083550145 @default.
• W2040403266 creator A5087712586 @default.
• W2040403266 creator A5088057956 @default.
• W2040403266 creator A5088568884 @default.
• W2040403266 date "2008-01-01" @default.
• W2040403266 modified "2023-09-27" @default.
• W2040403266 title "Characterization of TBX20 in human hearts and its regulation by TFAP2" @default.
• W2040403266 cites W1228798347 @default.
• W2040403266 cites W1577577364 @default.
• W2040403266 cites W1590222977 @default.
• W2040403266 cites W1760771044 @default.
• W2040403266 cites W1860599747 @default.
• W2040403266 cites W1944778414 @default.
• W2040403266 cites W1989457690 @default.
• W2040403266 cites W1994446230 @default.
• W2040403266 cites W1999913971 @default.
• W2040403266 cites W2006045768 @default.
• W2040403266 cites W2010390017 @default.
• W2040403266 cites W2015082418 @default.
• W2040403266 cites W2022058321 @default.
• W2040403266 cites W2023359307 @default.
• W2040403266 cites W2036768270 @default.
• W2040403266 cites W2037601306 @default.
• W2040403266 cites W2040489034 @default.
• W2040403266 cites W2040686597 @default.
• W2040403266 cites W2045998016 @default.
• W2040403266 cites W2056546982 @default.
• W2040403266 cites W2058849934 @default.
• W2040403266 cites W2061884629 @default.
• W2040403266 cites W2063650823 @default.
• W2040403266 cites W207413701 @default.
• W2040403266 cites W2075347688 @default.
• W2040403266 cites W2078475439 @default.
• W2040403266 cites W2083248934 @default.
• W2040403266 cites W2084212386 @default.
• W2040403266 cites W2096418253 @default.
• W2040403266 cites W2097836010 @default.
• W2040403266 cites W2101735975 @default.
• W2040403266 cites W2113431091 @default.
• W2040403266 cites W2127387556 @default.
• W2040403266 cites W2148559371 @default.
• W2040403266 cites W2154847292 @default.
• W2040403266 cites W2157304951 @default.
• W2040403266 cites W2160003307 @default.
• W2040403266 cites W2166898290 @default.
• W2040403266 cites W2254174322 @default.
• W2040403266 cites W2917355555 @default.
• W2040403266 doi "https://doi.org/10.1002/jcb.21686" @default.
• W2040403266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18275040" @default.
• W2040403266 hasPublicationYear "2008" @default.
• W2040403266 type Work @default.
• W2040403266 sameAs 2040403266 @default.
• W2040403266 citedByCount "53" @default.
• W2040403266 countsByYear W20404032662012 @default.
• W2040403266 countsByYear W20404032662013 @default.
• W2040403266 countsByYear W20404032662014 @default.
• W2040403266 countsByYear W20404032662015 @default.
• W2040403266 countsByYear W20404032662016 @default.
• W2040403266 countsByYear W20404032662017 @default.
• W2040403266 countsByYear W20404032662018 @default.
• W2040403266 countsByYear W20404032662019 @default.
• W2040403266 countsByYear W20404032662020 @default.
• W2040403266 countsByYear W20404032662021 @default.
• W2040403266 countsByYear W20404032662022 @default.
• W2040403266 countsByYear W20404032662023 @default.
• W2040403266 crossrefType "journal-article" @default.
• W2040403266 hasAuthorship W2040403266A5001062617 @default.
• W2040403266 hasAuthorship W2040403266A5007168347 @default.
• W2040403266 hasAuthorship W2040403266A5015618150 @default.
• W2040403266 hasAuthorship W2040403266A5035857958 @default.
• W2040403266 hasAuthorship W2040403266A5062147292 @default.
• W2040403266 hasAuthorship W2040403266A5079184552 @default.
• W2040403266 hasAuthorship W2040403266A5083550145 @default.
• W2040403266 hasAuthorship W2040403266A5087712586 @default.
• W2040403266 hasAuthorship W2040403266A5088057956 @default.
• W2040403266 hasAuthorship W2040403266A5088568884 @default.
• W2040403266 hasConcept C104317684 @default.
• W2040403266 hasConcept C142724271 @default.
• W2040403266 hasConcept C145103041 @default.
• W2040403266 hasConcept C146291010 @default.
• W2040403266 hasConcept C2778646171 @default.
• W2040403266 hasConcept C2780074459 @default.
• W2040403266 hasConcept C54355233 @default.
• W2040403266 hasConcept C62425271 @default.
• W2040403266 hasConcept C71924100 @default.
• W2040403266 hasConcept C86339819 @default.
• W2040403266 hasConcept C86803240 @default.
• W2040403266 hasConceptScore W2040403266C104317684 @default.
• W2040403266 hasConceptScore W2040403266C142724271 @default.
• W2040403266 hasConceptScore W2040403266C145103041 @default.

• next