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- W2040405306 abstract "Glomerulonephritis was found in Afghan pikas (Ochotona rufescens rufescens) that we kept free of specific pathogens. Age-dependent development of proteinuria and azotemia was observed. Hemosiderosis was histologically revealed in the liver. Anemia was detected after 3 months of age. Serum autoantibodies including antinuclear antibodies, and antierythrocyte antibodies were found. The staining pattern of the antinuclear antibodies was of the speckled type. The direct Coombs' test was positive for the majority of the red blood cell samples taken from pikas older than 2 months. The indirect Coombs' test was positive only for 18% of the femal sera. Deposition of immunoglobulins in the glomeruli was demonstrated by immunofluorescence, using FITC-anti-pika Ig antibody. Electron microscopy also showed deposits in the glomerular mesangial matrix. The results suggest that glomerulonephritis and anemia in the Afghan pika involve autoimmune pathogenetic mechanisms." @default.
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- W2040405306 date "1981-12-01" @default.
- W2040405306 modified "2023-09-30" @default.
- W2040405306 title "Autoimmune glomerulonephritis and hemolytic anemia in a new laboratory animal, the Afghan pika" @default.
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- W2040405306 doi "https://doi.org/10.1016/0090-1229(81)90226-9" @default.
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