FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040406188> ?p ?o ?g. }

• W2040406188 endingPage "68" @default.
• W2040406188 startingPage "55" @default.
• W2040406188 abstract "Abstract BACKGROUND: VLA‐4 (Very late antigen 4, integrin α 4 β 1 ) plays an important role in cell‐cell interactions that are critical for development. Homozygous null knockouts of the α 4 subunit of VLA‐4 or VCAM‐1 (cell surface ligand to VLA‐4) in mice result in abnormal placental and cardiac development and embryo lethality. Objectives of the current study were to assess and compare the teratogenic potential of three VLA‐4 antagonists. METHODS: IVL745, HMR1031, and IVL984 were each evaluated by the subcutaneous route in standard embryo‐fetal developmental toxicity studies in rats and rabbits. IVL984 was also evaluated in mice. Fetuses were examined externally, viscerally, and skeletally. RESULTS: IVL745 did not cause significant maternal or fetal effects at doses up to 100 or 250 mg/kg/day in rats or rabbits, respectively. HMR1031 treatment resulted in marked maternal toxicity and slight fetal toxicity at the highest tested doses of 200 and 75 mg/kg/day in rats and rabbits, respectively. HMR1031 embryo‐fetal effects consisted of slightly lower body weight and crown‐rump length in rats and minor sternebral defects in rabbits. IVL984 treatment resulted in minimal maternal effects at doses up to 40, 15, and 100 mg/kg/day in rats, rabbits, and mice, respectively (excluding abortions in rabbits). However, marked developmental effects were observed at the lowest tested IVL984 doses, 1, 0.2, and 3 mg/kg/day in rats, rabbits, and mice, respectively. IVL984 embryo‐fetal effects consisted of increased total post‐implantation loss due to early resorptions and high incidences of cardiac malformations and skeletal malformations and/or variations. Notably, spiral septal defects were observed in up to 76% of rat fetuses and up to 58% of rabbit fetuses. CONCLUSIONS: Dramatic differences in teratogenic potential were observed: IVL745 was not teratogenic, HMR1031 caused slight embryo‐fetal effects at maternally‐toxic doses, and IVL984 was a potent teratogen at doses where direct maternal toxicity was limited to abortions in rabbits. Prominent effects of IVL984 included embryo lethality and cardiac malformations including spiral septal defects in three species. Birth Defects Res B 71:55–68, 2004. © 2004 Wiley‐Liss, Inc." @default.
• W2040406188 created "2016-06-24" @default.
• W2040406188 creator A5006113825 @default.
• W2040406188 creator A5007119969 @default.
• W2040406188 creator A5011817433 @default.
• W2040406188 creator A5015900915 @default.
• W2040406188 creator A5027219289 @default.
• W2040406188 creator A5034159705 @default.
• W2040406188 creator A5050051530 @default.
• W2040406188 creator A5057980708 @default.
• W2040406188 creator A5071960172 @default.
• W2040406188 creator A5073326332 @default.
• W2040406188 creator A5075870405 @default.
• W2040406188 date "2004-04-01" @default.
• W2040406188 modified "2023-10-14" @default.
• W2040406188 title "Different embryo-fetal toxicity effects for three VLA-4 antagonists" @default.
• W2040406188 cites W1939326986 @default.
• W2040406188 cites W1970309224 @default.
• W2040406188 cites W1973218901 @default.
• W2040406188 cites W1994149163 @default.
• W2040406188 cites W2003142240 @default.
• W2040406188 cites W2055784851 @default.
• W2040406188 cites W2080785373 @default.
• W2040406188 cites W2084368735 @default.
• W2040406188 cites W2094868974 @default.
• W2040406188 cites W2137068071 @default.
• W2040406188 cites W2163666397 @default.
• W2040406188 cites W2197227471 @default.
• W2040406188 cites W2332205625 @default.
• W2040406188 cites W2332863137 @default.
• W2040406188 cites W4236579955 @default.
• W2040406188 doi "https://doi.org/10.1002/bdrb.20001" @default.
• W2040406188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15098199" @default.
• W2040406188 hasPublicationYear "2004" @default.
• W2040406188 type Work @default.
• W2040406188 sameAs 2040406188 @default.
• W2040406188 citedByCount "15" @default.
• W2040406188 countsByYear W20404061882013 @default.
• W2040406188 countsByYear W20404061882014 @default.
• W2040406188 countsByYear W20404061882019 @default.
• W2040406188 crossrefType "journal-article" @default.
• W2040406188 hasAuthorship W2040406188A5006113825 @default.
• W2040406188 hasAuthorship W2040406188A5007119969 @default.
• W2040406188 hasAuthorship W2040406188A5011817433 @default.
• W2040406188 hasAuthorship W2040406188A5015900915 @default.
• W2040406188 hasAuthorship W2040406188A5027219289 @default.
• W2040406188 hasAuthorship W2040406188A5034159705 @default.
• W2040406188 hasAuthorship W2040406188A5050051530 @default.
• W2040406188 hasAuthorship W2040406188A5057980708 @default.
• W2040406188 hasAuthorship W2040406188A5071960172 @default.
• W2040406188 hasAuthorship W2040406188A5073326332 @default.
• W2040406188 hasAuthorship W2040406188A5075870405 @default.
• W2040406188 hasConcept C126322002 @default.
• W2040406188 hasConcept C134018914 @default.
• W2040406188 hasConcept C16685009 @default.
• W2040406188 hasConcept C172680121 @default.
• W2040406188 hasConcept C179335377 @default.
• W2040406188 hasConcept C196843134 @default.
• W2040406188 hasConcept C2779234561 @default.
• W2040406188 hasConcept C29730261 @default.
• W2040406188 hasConcept C54355233 @default.
• W2040406188 hasConcept C65290608 @default.
• W2040406188 hasConcept C71924100 @default.
• W2040406188 hasConcept C86803240 @default.
• W2040406188 hasConcept C95444343 @default.
• W2040406188 hasConceptScore W2040406188C126322002 @default.
• W2040406188 hasConceptScore W2040406188C134018914 @default.
• W2040406188 hasConceptScore W2040406188C16685009 @default.
• W2040406188 hasConceptScore W2040406188C172680121 @default.
• W2040406188 hasConceptScore W2040406188C179335377 @default.
• W2040406188 hasConceptScore W2040406188C196843134 @default.
• W2040406188 hasConceptScore W2040406188C2779234561 @default.
• W2040406188 hasConceptScore W2040406188C29730261 @default.
• W2040406188 hasConceptScore W2040406188C54355233 @default.
• W2040406188 hasConceptScore W2040406188C65290608 @default.
• W2040406188 hasConceptScore W2040406188C71924100 @default.
• W2040406188 hasConceptScore W2040406188C86803240 @default.
• W2040406188 hasConceptScore W2040406188C95444343 @default.
• W2040406188 hasIssue "2" @default.
• W2040406188 hasLocation W20404061881 @default.
• W2040406188 hasLocation W20404061882 @default.
• W2040406188 hasOpenAccess W2040406188 @default.
• W2040406188 hasPrimaryLocation W20404061881 @default.
• W2040406188 hasRelatedWork W1502739263 @default.
• W2040406188 hasRelatedWork W2011335313 @default.
• W2040406188 hasRelatedWork W2019843999 @default.
• W2040406188 hasRelatedWork W2031323776 @default.
• W2040406188 hasRelatedWork W2044066565 @default.
• W2040406188 hasRelatedWork W2082154626 @default.
• W2040406188 hasRelatedWork W2090657610 @default.
• W2040406188 hasRelatedWork W2110908042 @default.
• W2040406188 hasRelatedWork W2118348231 @default.
• W2040406188 hasRelatedWork W4254304303 @default.
• W2040406188 hasVolume "71" @default.
• W2040406188 isParatext "false" @default.
• W2040406188 isRetracted "false" @default.
• W2040406188 magId "2040406188" @default.
• W2040406188 workType "article" @default.