Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040409790> ?p ?o ?g. }
- W2040409790 endingPage "184" @default.
- W2040409790 startingPage "175" @default.
- W2040409790 abstract "Animal models of hemophilia and related diseases are important for the development of novel treatments and to understand the pathophysiology of bleeding disorders in humans. Testing in animals with the equivalent human disorder provides informed estimates of doses and measures of efficacy, which aids in design of human trials. Many models of hemophilia A, hemophilia B, and von Willebrand disease (VWD) have been developed from animals with spontaneous mutations (hemophilia A dogs, rats, sheep; hemophilia B dogs; and VWD pigs and dogs), or by targeted gene disruption in mice to create hemophilia A, B, or VWD models. Animal models have been used to generate new insights into the pathophysiology of each bleeding disorder and also to perform preclinical assessments of standard protein replacement therapies, as well as novel gene transfer technology. The differences both between species and in underlying causative mutations must be considered in choosing the best animal for a specific scientific study." @default.
- W2040409790 created "2016-06-24" @default.
- W2040409790 creator A5038704186 @default.
- W2040409790 creator A5052704460 @default.
- W2040409790 date "2013-04-01" @default.
- W2040409790 modified "2023-09-24" @default.
- W2040409790 title "Animal Models of Hemophilia and Related Bleeding Disorders" @default.
- W2040409790 cites W1255418244 @default.
- W2040409790 cites W128358802 @default.
- W2040409790 cites W13586132 @default.
- W2040409790 cites W148295968 @default.
- W2040409790 cites W1484090672 @default.
- W2040409790 cites W1487084354 @default.
- W2040409790 cites W1519546700 @default.
- W2040409790 cites W1565788467 @default.
- W2040409790 cites W1569674809 @default.
- W2040409790 cites W1581969514 @default.
- W2040409790 cites W164651796 @default.
- W2040409790 cites W177468018 @default.
- W2040409790 cites W1888320884 @default.
- W2040409790 cites W1927036797 @default.
- W2040409790 cites W1964975805 @default.
- W2040409790 cites W1973039456 @default.
- W2040409790 cites W1976158989 @default.
- W2040409790 cites W1976329054 @default.
- W2040409790 cites W1976345010 @default.
- W2040409790 cites W1978519692 @default.
- W2040409790 cites W1978668313 @default.
- W2040409790 cites W1984902064 @default.
- W2040409790 cites W1985872523 @default.
- W2040409790 cites W1988291930 @default.
- W2040409790 cites W1989888025 @default.
- W2040409790 cites W1994849771 @default.
- W2040409790 cites W1995076136 @default.
- W2040409790 cites W1998392237 @default.
- W2040409790 cites W2012010994 @default.
- W2040409790 cites W2014818093 @default.
- W2040409790 cites W2016608925 @default.
- W2040409790 cites W2019932049 @default.
- W2040409790 cites W2024506826 @default.
- W2040409790 cites W2025427080 @default.
- W2040409790 cites W2026922732 @default.
- W2040409790 cites W2027217170 @default.
- W2040409790 cites W2036877355 @default.
- W2040409790 cites W2041157989 @default.
- W2040409790 cites W2041489036 @default.
- W2040409790 cites W2047790770 @default.
- W2040409790 cites W2052218777 @default.
- W2040409790 cites W2053957384 @default.
- W2040409790 cites W2062401654 @default.
- W2040409790 cites W2062893986 @default.
- W2040409790 cites W2063613634 @default.
- W2040409790 cites W2066192964 @default.
- W2040409790 cites W2067695390 @default.
- W2040409790 cites W206975662 @default.
- W2040409790 cites W2075013504 @default.
- W2040409790 cites W2075478741 @default.
- W2040409790 cites W2077290326 @default.
- W2040409790 cites W2077333708 @default.
- W2040409790 cites W2078640978 @default.
- W2040409790 cites W2083384782 @default.
- W2040409790 cites W2083788869 @default.
- W2040409790 cites W2089745978 @default.
- W2040409790 cites W2101385709 @default.
- W2040409790 cites W2104680298 @default.
- W2040409790 cites W2110318546 @default.
- W2040409790 cites W2110881562 @default.
- W2040409790 cites W2111742323 @default.
- W2040409790 cites W2116780185 @default.
- W2040409790 cites W2116868364 @default.
- W2040409790 cites W2117303551 @default.
- W2040409790 cites W2122304523 @default.
- W2040409790 cites W2126618978 @default.
- W2040409790 cites W2130515212 @default.
- W2040409790 cites W2133686229 @default.
- W2040409790 cites W2139340234 @default.
- W2040409790 cites W2145365087 @default.
- W2040409790 cites W2149925405 @default.
- W2040409790 cites W2150144434 @default.
- W2040409790 cites W2153386394 @default.
- W2040409790 cites W2153867928 @default.
- W2040409790 cites W2154530436 @default.
- W2040409790 cites W2155710930 @default.
- W2040409790 cites W2165167860 @default.
- W2040409790 cites W2165909566 @default.
- W2040409790 cites W2169344158 @default.
- W2040409790 cites W2269518937 @default.
- W2040409790 cites W230816652 @default.
- W2040409790 cites W2342669975 @default.
- W2040409790 cites W2408914345 @default.
- W2040409790 cites W2413280868 @default.
- W2040409790 cites W2415572414 @default.
- W2040409790 cites W2435469686 @default.
- W2040409790 cites W3110701567 @default.
- W2040409790 cites W4248849693 @default.
- W2040409790 cites W89695908 @default.
- W2040409790 doi "https://doi.org/10.1053/j.seminhematol.2013.03.023" @default.
- W2040409790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742033" @default.