Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040411362> ?p ?o ?g. }
- W2040411362 endingPage "12" @default.
- W2040411362 startingPage "1" @default.
- W2040411362 abstract "Metastasis remains the most deadly aspect of cancer and still evades direct treatment. Thus, there is a great need to develop new treatment regimens to suppress tumor cells that have escaped surgical removal or that may have already disseminated. We have found that tetrandrine (TET) exhibits anticolon cancer activity. Here, we investigate the inhibition effect of TET to breast cancer metastasis, angiogenesis and its molecular basis underlying TET’s anticancer activity. We compare TET with chemotherapy drug doxorubicin in 4T1 tumor bearing BALB/c mice model and find that TET exhibits an anticancer metastatic and antiangiogenic activities better than those of doxorubicin. The lung metastatic sites were decreased by TET, which is confirmed by bioluminescence imaging in vivo . On the other hand, laser doppler perfusion imaging (LDI) was used for measuring the blood flow of tumor in 4T1-tumor bearing mice. As a result, the local blood perfusion of tumor was markedly decreased by TET after 3 weeks. Mechanistically, TET treatment leads to a decrease in p-ERK level and an increase in NF- κ B levels in HUVECs. TET also regulated metastatic and angiogenic related proteins, including vascular endothelial growth factor, hypoxia-inducible factor-1 α , integrin β 5, endothelial cell specific molecule-1, and intercellular adhesion molecule-1 in vivo ." @default.
- W2040411362 created "2016-06-24" @default.
- W2040411362 creator A5001610191 @default.
- W2040411362 creator A5005848875 @default.
- W2040411362 creator A5007527362 @default.
- W2040411362 creator A5012549429 @default.
- W2040411362 creator A5026984704 @default.
- W2040411362 creator A5056754256 @default.
- W2040411362 creator A5070578608 @default.
- W2040411362 creator A5089921461 @default.
- W2040411362 date "2013-01-01" @default.
- W2040411362 modified "2023-10-14" @default.
- W2040411362 title "Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice" @default.
- W2040411362 cites W1768995798 @default.
- W2040411362 cites W1964433907 @default.
- W2040411362 cites W1969443094 @default.
- W2040411362 cites W1971475600 @default.
- W2040411362 cites W1973935214 @default.
- W2040411362 cites W1974777081 @default.
- W2040411362 cites W1975078638 @default.
- W2040411362 cites W1976356091 @default.
- W2040411362 cites W1980076270 @default.
- W2040411362 cites W1994871740 @default.
- W2040411362 cites W1994899079 @default.
- W2040411362 cites W1996251685 @default.
- W2040411362 cites W2004696054 @default.
- W2040411362 cites W2011411577 @default.
- W2040411362 cites W2011761515 @default.
- W2040411362 cites W2021925807 @default.
- W2040411362 cites W2022936070 @default.
- W2040411362 cites W2048446768 @default.
- W2040411362 cites W2049479990 @default.
- W2040411362 cites W2062195965 @default.
- W2040411362 cites W2069798744 @default.
- W2040411362 cites W2069969595 @default.
- W2040411362 cites W2075656767 @default.
- W2040411362 cites W2084990113 @default.
- W2040411362 cites W2085813403 @default.
- W2040411362 cites W2086798060 @default.
- W2040411362 cites W2091728033 @default.
- W2040411362 cites W2100596948 @default.
- W2040411362 cites W2108713158 @default.
- W2040411362 cites W2108944203 @default.
- W2040411362 cites W2114882308 @default.
- W2040411362 cites W2119882791 @default.
- W2040411362 cites W2132316821 @default.
- W2040411362 cites W2143343444 @default.
- W2040411362 cites W2144348878 @default.
- W2040411362 cites W2145039371 @default.
- W2040411362 cites W2147188402 @default.
- W2040411362 cites W2153920367 @default.
- W2040411362 cites W2168636998 @default.
- W2040411362 doi "https://doi.org/10.1155/2013/265061" @default.
- W2040411362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3677646" @default.
- W2040411362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23762115" @default.
- W2040411362 hasPublicationYear "2013" @default.
- W2040411362 type Work @default.
- W2040411362 sameAs 2040411362 @default.
- W2040411362 citedByCount "33" @default.
- W2040411362 countsByYear W20404113622013 @default.
- W2040411362 countsByYear W20404113622014 @default.
- W2040411362 countsByYear W20404113622015 @default.
- W2040411362 countsByYear W20404113622016 @default.
- W2040411362 countsByYear W20404113622017 @default.
- W2040411362 countsByYear W20404113622018 @default.
- W2040411362 countsByYear W20404113622019 @default.
- W2040411362 countsByYear W20404113622020 @default.
- W2040411362 countsByYear W20404113622021 @default.
- W2040411362 countsByYear W20404113622022 @default.
- W2040411362 crossrefType "journal-article" @default.
- W2040411362 hasAuthorship W2040411362A5001610191 @default.
- W2040411362 hasAuthorship W2040411362A5005848875 @default.
- W2040411362 hasAuthorship W2040411362A5007527362 @default.
- W2040411362 hasAuthorship W2040411362A5012549429 @default.
- W2040411362 hasAuthorship W2040411362A5026984704 @default.
- W2040411362 hasAuthorship W2040411362A5056754256 @default.
- W2040411362 hasAuthorship W2040411362A5070578608 @default.
- W2040411362 hasAuthorship W2040411362A5089921461 @default.
- W2040411362 hasBestOaLocation W20404113621 @default.
- W2040411362 hasConcept C111335760 @default.
- W2040411362 hasConcept C121608353 @default.
- W2040411362 hasConcept C126322002 @default.
- W2040411362 hasConcept C142724271 @default.
- W2040411362 hasConcept C150903083 @default.
- W2040411362 hasConcept C161997846 @default.
- W2040411362 hasConcept C167734588 @default.
- W2040411362 hasConcept C207001950 @default.
- W2040411362 hasConcept C2776694085 @default.
- W2040411362 hasConcept C2777025900 @default.
- W2040411362 hasConcept C2778271429 @default.
- W2040411362 hasConcept C2779013556 @default.
- W2040411362 hasConcept C2779934757 @default.
- W2040411362 hasConcept C2780394083 @default.
- W2040411362 hasConcept C2781303535 @default.
- W2040411362 hasConcept C502942594 @default.
- W2040411362 hasConcept C54009773 @default.
- W2040411362 hasConcept C54355233 @default.
- W2040411362 hasConcept C71924100 @default.