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- W2040421852 abstract "Intravenous or intraperitoneal injections of mercuric chloride (5 mg Hg/kg) into mice resulted in an inhibition of proteolytic activity in isolated kidney heterolysosomes containing intravenously injected denatured (formaldehyde) 125I-albumin but not in these particles from the liver. The inhibition occurred if the mercuric chloride was injected up to about 17 hr before injection of labeled protein. The proportion of particle-bound radioactivity which could be released by osmotic shock was substantially decreased in subcellular suspensions from mercury-injected mice. In some experiments therefore, digestive rates were normal in mercury-injected mice if proteolysis was measured in terms of the osmotically releasable radioactivity rather than in terms of the total particle-bound material. This suggest that mercury inhibited either endocytosis of labeled protein or heterolysosome formation. However, in most experiments in which digestion was measured in the presence and absence of mercaptoethanol, stimulation of proteolysis by mercaptoethanol was significantly greater in heterolysosomes from mercury-injected animals than in the controls. This suggests that mercury affected proteolytic activity within the organelles as well as heterolysosome formation." @default.
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- W2040421852 date "1973-02-01" @default.
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- W2040421852 title "Inhibition of heterolysosome formation and function in mouse kidneys by injection of mercuric chloride" @default.
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- W2040421852 doi "https://doi.org/10.1016/0006-2952(73)90418-8" @default.
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