FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040430011> ?p ?o ?g. }

• W2040430011 endingPage "1615" @default.
• W2040430011 startingPage "1608" @default.
• W2040430011 abstract "Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease with a multifactorial pathogenesis and increasing incidence in the Western world. A genetically determined defective function of pattern recognition receptors such as toll-like receptors (TLRs) has been proposed as a candidate mechanism in the pathogenesis of AD. Aim: To study the impact of genetic predisposition of five genes encoding for pattern recognition-related molecules for the phenotype of AD. Methods: We examined nine different single-nucleotide polymorphism (SNP) frequencies in the genes encoding TLR1, -2, -4, -9 and the adapter molecule TIRAP by PCR with subsequent melting curve analysis in a case/control cohort of 136 adult AD patients and 129 age and gender matched non-atopic, healthy individuals. TLR2-expression and -function in cells from genotyped individuals were analysed. Results: For the SNPs examined, similar genotype frequencies were found in both groups. In a subgroup of patients suffering from severe AD (SCORAD >50), a significantly increased representation of the A-allele in position –16934 of the tlr2 gene was present (P = 0.004). Constitutive tlr2 mRNA expression in peripheral monocytes was independent of this tlr2 promoter SNP. Stimulation assays indicated that IL-6, but not TNF-α secretion following TLR2 stimulation is reduced in homozygous tlr2-16934-A allele carriers. Conclusion: These data indicate that TLR2 is relevant for the phenotype of severe AD in adults." @default.
• W2040430011 created "2016-06-24" @default.
• W2040430011 creator A5017177846 @default.
• W2040430011 creator A5020269983 @default.
• W2040430011 creator A5037964204 @default.
• W2040430011 creator A5048797041 @default.
• W2040430011 creator A5053430723 @default.
• W2040430011 creator A5053887656 @default.
• W2040430011 date "2009-11-01" @default.
• W2040430011 modified "2023-10-02" @default.
• W2040430011 title "Association of the<i>toll-like receptor 2</i>A-16934T promoter polymorphism with severe atopic dermatitis" @default.
• W2040430011 cites W1582490802 @default.
• W2040430011 cites W1585126227 @default.
• W2040430011 cites W1988161503 @default.
• W2040430011 cites W1990142540 @default.
• W2040430011 cites W1992151583 @default.
• W2040430011 cites W1994364461 @default.
• W2040430011 cites W1998055077 @default.
• W2040430011 cites W2003381671 @default.
• W2040430011 cites W2008003223 @default.
• W2040430011 cites W2010566621 @default.
• W2040430011 cites W2024156097 @default.
• W2040430011 cites W2035831689 @default.
• W2040430011 cites W2038486513 @default.
• W2040430011 cites W2041243178 @default.
• W2040430011 cites W2046423800 @default.
• W2040430011 cites W2052997401 @default.
• W2040430011 cites W2054538617 @default.
• W2040430011 cites W2054570534 @default.
• W2040430011 cites W2056299785 @default.
• W2040430011 cites W2091229884 @default.
• W2040430011 cites W2104422361 @default.
• W2040430011 cites W2107762058 @default.
• W2040430011 cites W2117773205 @default.
• W2040430011 cites W2118016322 @default.
• W2040430011 cites W2119985244 @default.
• W2040430011 cites W2132507498 @default.
• W2040430011 cites W2133449490 @default.
• W2040430011 cites W2135856234 @default.
• W2040430011 cites W2151777859 @default.
• W2040430011 cites W2155525029 @default.
• W2040430011 cites W2155912911 @default.
• W2040430011 cites W2158868184 @default.
• W2040430011 cites W2162201817 @default.
• W2040430011 cites W2162624882 @default.
• W2040430011 doi "https://doi.org/10.1111/j.1398-9995.2009.02066.x" @default.
• W2040430011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19627277" @default.
• W2040430011 hasPublicationYear "2009" @default.
• W2040430011 type Work @default.
• W2040430011 sameAs 2040430011 @default.
• W2040430011 citedByCount "89" @default.
• W2040430011 countsByYear W20404300112012 @default.
• W2040430011 countsByYear W20404300112013 @default.
• W2040430011 countsByYear W20404300112014 @default.
• W2040430011 countsByYear W20404300112015 @default.
• W2040430011 countsByYear W20404300112016 @default.
• W2040430011 countsByYear W20404300112017 @default.
• W2040430011 countsByYear W20404300112018 @default.
• W2040430011 countsByYear W20404300112019 @default.
• W2040430011 countsByYear W20404300112020 @default.
• W2040430011 countsByYear W20404300112021 @default.
• W2040430011 countsByYear W20404300112022 @default.
• W2040430011 countsByYear W20404300112023 @default.
• W2040430011 crossrefType "journal-article" @default.
• W2040430011 hasAuthorship W2040430011A5017177846 @default.
• W2040430011 hasAuthorship W2040430011A5020269983 @default.
• W2040430011 hasAuthorship W2040430011A5037964204 @default.
• W2040430011 hasAuthorship W2040430011A5048797041 @default.
• W2040430011 hasAuthorship W2040430011A5053430723 @default.
• W2040430011 hasAuthorship W2040430011A5053887656 @default.
• W2040430011 hasConcept C104317684 @default.
• W2040430011 hasConcept C135763542 @default.
• W2040430011 hasConcept C139275648 @default.
• W2040430011 hasConcept C153209595 @default.
• W2040430011 hasConcept C170493617 @default.
• W2040430011 hasConcept C180754005 @default.
• W2040430011 hasConcept C203014093 @default.
• W2040430011 hasConcept C2776070231 @default.
• W2040430011 hasConcept C2776173921 @default.
• W2040430011 hasConcept C2778329239 @default.
• W2040430011 hasConcept C2780501606 @default.
• W2040430011 hasConcept C2780564577 @default.
• W2040430011 hasConcept C2780942790 @default.
• W2040430011 hasConcept C2781236682 @default.
• W2040430011 hasConcept C54355233 @default.
• W2040430011 hasConcept C71924100 @default.
• W2040430011 hasConcept C86803240 @default.
• W2040430011 hasConceptScore W2040430011C104317684 @default.
• W2040430011 hasConceptScore W2040430011C135763542 @default.
• W2040430011 hasConceptScore W2040430011C139275648 @default.
• W2040430011 hasConceptScore W2040430011C153209595 @default.
• W2040430011 hasConceptScore W2040430011C170493617 @default.
• W2040430011 hasConceptScore W2040430011C180754005 @default.
• W2040430011 hasConceptScore W2040430011C203014093 @default.
• W2040430011 hasConceptScore W2040430011C2776070231 @default.
• W2040430011 hasConceptScore W2040430011C2776173921 @default.
• W2040430011 hasConceptScore W2040430011C2778329239 @default.
• W2040430011 hasConceptScore W2040430011C2780501606 @default.

• next