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- W2040431921 endingPage "66" @default.
- W2040431921 startingPage "46" @default.
- W2040431921 abstract "Modern imaging methods provide unprecedented insights into brain structure, perfusion, metabolism, and neurochemistry, both during and between migraine attacks. Neuroimaging investigations conducted in recent decades bring us closer to uncovering migraine as a multifaceted, primarily central nervous system disorder. Three main categories of structural and functional brain changes are described in this review, corresponding to the migrainous aura, ictal headache, and interictal states. These changes greatly advance our understanding of multiple pathophysiologic underpinnings of migraine, from central “migraine generating” loci, to cortical spreading depression, intimate mechanisms underlying activation of neuronal pain pathways in vulnerable patients, central sensitization, and chronification. Structural imaging begins to explain the complex connections between migraine and cerebral vascular events, white matter lesions, grey matter density alterations, iron deposition, and microstructural brain damage. Selected structural and functional alterations of brain structures, as identified with imaging methods, may represent the foundation of new diagnostic strategies and serve as markers of therapeutic efficacy." @default.
- W2040431921 created "2016-06-24" @default.
- W2040431921 creator A5062717433 @default.
- W2040431921 creator A5064341657 @default.
- W2040431921 creator A5079941092 @default.
- W2040431921 date "2012-10-23" @default.
- W2040431921 modified "2023-10-17" @default.
- W2040431921 title "Structural and Functional Neuroimaging in Migraine: Insights From 3 Decades of Research" @default.
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