FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040432876> ?p ?o ?g. }

• W2040432876 endingPage "421" @default.
• W2040432876 startingPage "413" @default.
• W2040432876 abstract "Biochemical and immunological properties of lymphocytes were measured repetitively over a period of 40 mo during enzyme replacement by transfusion in a child with adenosine deaminase (ADA) deficiency and severe combined immunodeficiency disease. Catalytically defective ADA protein is present in the child's cells. ADA activity in his lymphocytes is 7 nmol/min per 10(8) cells with 51 ng of ADA protein/10(8) cells by radioimmunoassay. ADA activities in normal cord and adult lymphocytes average 193 and 92 nmol/min per 10(8) cells, respectively, with 429 and 223 ng of ADA protein/10(8) cells. Deoxy(d)ATP accumulates in the patient's erythrocytes and lymphocytes. Transfusion of irradiated packed erythrocytes partially corrects the metabolic defects. Frank metabolic relapse occurs if transfusions are discontinued for several months. The amounts of dATP in erythrocytes and lymphocytes averaged 13 and 2 times normal, respectively, during periods when transfusions were administered every 2-4 wk. Deoxyguanosine triphosphate and deoxycytidine triphosphate in lymphocytes were normal on 11 occasions, but deoxyribosylthymine triphosphate was ninefold increased. On 11 occasions dATP was measured in lymphocytes and erythrocytes isolated simultaneously. There was a positive, but statistically insignificant, correlation between amounts of dATP in the two types of cells (r = 0.25,P > 0.1). The absolute peripheral lymphocyte count was correlated with the activity of ADA in circulating erythrocytes and with the response of lymphocytes to phytohemagglutinin (r = 0.64, P < 0.01; r = 0.49, P < 0.05). Response of lymphocytes to stimulation by phytohemagglutinin in vitro and absolute peripheral lymphocyte counts were not significantly correlated with levels of dATP in the erythrocyte or lymphocyte during periods of intensive therapy. Although there was objective improvement during enzyme replacement, the child remained immunodeficient and biochemically abnormal." @default.
• W2040432876 created "2016-06-24" @default.
• W2040432876 creator A5012695189 @default.
• W2040432876 creator A5015446452 @default.
• W2040432876 creator A5018049201 @default.
• W2040432876 creator A5042134726 @default.
• W2040432876 creator A5051707397 @default.
• W2040432876 creator A5085329784 @default.
• W2040432876 date "1981-08-01" @default.
• W2040432876 modified "2023-09-26" @default.
• W2040432876 title "Biochemical and Functional Abnormalities in Lymphocytes from an Adenosine Deaminase-deficient Patient during Enzyme Replacement Therapy" @default.
• W2040432876 cites W152601127 @default.
• W2040432876 cites W1532312316 @default.
• W2040432876 cites W1533424665 @default.
• W2040432876 cites W1563905113 @default.
• W2040432876 cites W1566751917 @default.
• W2040432876 cites W1577497947 @default.
• W2040432876 cites W1975308296 @default.
• W2040432876 cites W1983559242 @default.
• W2040432876 cites W1990786530 @default.
• W2040432876 cites W1993720912 @default.
• W2040432876 cites W1999516176 @default.
• W2040432876 cites W2003852378 @default.
• W2040432876 cites W2007841236 @default.
• W2040432876 cites W2031890808 @default.
• W2040432876 cites W2032726911 @default.
• W2040432876 cites W2032848431 @default.
• W2040432876 cites W2048083555 @default.
• W2040432876 cites W2060305521 @default.
• W2040432876 cites W2065221119 @default.
• W2040432876 cites W2071804585 @default.
• W2040432876 cites W2079575984 @default.
• W2040432876 cites W2079752228 @default.
• W2040432876 cites W2098476077 @default.
• W2040432876 cites W2128226258 @default.
• W2040432876 cites W2133667646 @default.
• W2040432876 cites W2145370011 @default.
• W2040432876 cites W2156374047 @default.
• W2040432876 cites W2228977654 @default.
• W2040432876 cites W2336950812 @default.
• W2040432876 cites W2418086793 @default.
• W2040432876 doi "https://doi.org/10.1172/jci110270" @default.
• W2040432876 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/370813" @default.
• W2040432876 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7263861" @default.
• W2040432876 hasPublicationYear "1981" @default.
• W2040432876 type Work @default.
• W2040432876 sameAs 2040432876 @default.
• W2040432876 citedByCount "32" @default.
• W2040432876 countsByYear W20404328762017 @default.
• W2040432876 crossrefType "journal-article" @default.
• W2040432876 hasAuthorship W2040432876A5012695189 @default.
• W2040432876 hasAuthorship W2040432876A5015446452 @default.
• W2040432876 hasAuthorship W2040432876A5018049201 @default.
• W2040432876 hasAuthorship W2040432876A5042134726 @default.
• W2040432876 hasAuthorship W2040432876A5051707397 @default.
• W2040432876 hasAuthorship W2040432876A5085329784 @default.
• W2040432876 hasBestOaLocation W20404328761 @default.
• W2040432876 hasConcept C126322002 @default.
• W2040432876 hasConcept C134018914 @default.
• W2040432876 hasConcept C153911025 @default.
• W2040432876 hasConcept C181199279 @default.
• W2040432876 hasConcept C185592680 @default.
• W2040432876 hasConcept C203014093 @default.
• W2040432876 hasConcept C24998067 @default.
• W2040432876 hasConcept C2776991684 @default.
• W2040432876 hasConcept C2777761686 @default.
• W2040432876 hasConcept C2779134260 @default.
• W2040432876 hasConcept C2779564974 @default.
• W2040432876 hasConcept C2779969927 @default.
• W2040432876 hasConcept C2781161190 @default.
• W2040432876 hasConcept C34628245 @default.
• W2040432876 hasConcept C55493867 @default.
• W2040432876 hasConcept C71924100 @default.
• W2040432876 hasConcept C86803240 @default.
• W2040432876 hasConceptScore W2040432876C126322002 @default.
• W2040432876 hasConceptScore W2040432876C134018914 @default.
• W2040432876 hasConceptScore W2040432876C153911025 @default.
• W2040432876 hasConceptScore W2040432876C181199279 @default.
• W2040432876 hasConceptScore W2040432876C185592680 @default.
• W2040432876 hasConceptScore W2040432876C203014093 @default.
• W2040432876 hasConceptScore W2040432876C24998067 @default.
• W2040432876 hasConceptScore W2040432876C2776991684 @default.
• W2040432876 hasConceptScore W2040432876C2777761686 @default.
• W2040432876 hasConceptScore W2040432876C2779134260 @default.
• W2040432876 hasConceptScore W2040432876C2779564974 @default.
• W2040432876 hasConceptScore W2040432876C2779969927 @default.
• W2040432876 hasConceptScore W2040432876C2781161190 @default.
• W2040432876 hasConceptScore W2040432876C34628245 @default.
• W2040432876 hasConceptScore W2040432876C55493867 @default.
• W2040432876 hasConceptScore W2040432876C71924100 @default.
• W2040432876 hasConceptScore W2040432876C86803240 @default.
• W2040432876 hasIssue "2" @default.
• W2040432876 hasLocation W20404328761 @default.
• W2040432876 hasLocation W20404328762 @default.
• W2040432876 hasLocation W20404328763 @default.
• W2040432876 hasLocation W20404328764 @default.
• W2040432876 hasOpenAccess W2040432876 @default.
• W2040432876 hasPrimaryLocation W20404328761 @default.

• next