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• W2040434554 abstract "Kidney cancer, blood vessel tumors (hemangioblastomas), and adrenal tumors (pheochromocytomas) are features of von Hippel–Lindau disease, which is caused by germline VHL mutations. VHL mutations are also common in sporadic kidney cancers and hemangioblastomas. The normal VHL gene product inhibits a transcription factor called hypoxia-inducible factor (HIF), which in turn controls a variety of growth factors including vascular endothelial growth factor (VEGF). Inhibition of HIF-dependent growth factors appears promising for the treatment of kidney cancer and hemangioblastomas." @default.
• W2040434554 created "2016-06-24" @default.
• W2040434554 creator A5088456751 @default.
• W2040434554 date "2005-06-01" @default.
• W2040434554 modified "2023-09-30" @default.
• W2040434554 title "von Hippel–Lindau-associated malignancies: Mechanisms and therapeutic opportunities" @default.
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• W2040434554 doi "https://doi.org/10.1016/j.ddmec.2005.04.003" @default.
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