Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040441424> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2040441424 endingPage "13536" @default.
- W2040441424 startingPage "13528" @default.
- W2040441424 abstract "Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia. The molecular basis of the organ-specific pathologies associated with CBS deficiency is unknown as is the significance of the reported interaction between CBS and Huntingtin protein. In this study, we have used the yeast two-hybrid approach to screen for proteins that interact with CBS and have identified several components of the sumoylation pathway including Ubc9, PIAS1, PIAS3, Pc2, and RanBPM. We demonstrate that CBS is modified by the small ubiquitin-like modifier-1 protein (SUMO-I) under both in vitro and in vivo conditions. Deletion analysis of CBS indicates that the C-terminal regulatory domain is required for interaction with proteins in the sumoylation machinery. Sumoylated CBS is present in the nucleus where it is associated with the nuclear scaffold. The discovery that CBS is a target of sumoylation adds another layer to the complex regulation of this enzyme and reveals a previously unknown residence for this protein, i.e., in the nucleus." @default.
- W2040441424 created "2016-06-24" @default.
- W2040441424 creator A5013907641 @default.
- W2040441424 creator A5015943195 @default.
- W2040441424 creator A5016267462 @default.
- W2040441424 date "2006-10-18" @default.
- W2040441424 modified "2023-09-24" @default.
- W2040441424 title "Human Cystathionine β-Synthase Is a Target for Sumoylation" @default.
- W2040441424 cites W1982341626 @default.
- W2040441424 cites W2003199010 @default.
- W2040441424 cites W2004722555 @default.
- W2040441424 cites W2007549861 @default.
- W2040441424 cites W2016166905 @default.
- W2040441424 cites W2076248216 @default.
- W2040441424 cites W2080861994 @default.
- W2040441424 cites W2081663028 @default.
- W2040441424 cites W2086660631 @default.
- W2040441424 cites W2089674453 @default.
- W2040441424 cites W2090291630 @default.
- W2040441424 cites W2102785478 @default.
- W2040441424 cites W2108423991 @default.
- W2040441424 cites W2108484297 @default.
- W2040441424 cites W2112604508 @default.
- W2040441424 cites W2166714586 @default.
- W2040441424 cites W2170962595 @default.
- W2040441424 cites W2172298521 @default.
- W2040441424 doi "https://doi.org/10.1021/bi0615644" @default.
- W2040441424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17087506" @default.
- W2040441424 hasPublicationYear "2006" @default.
- W2040441424 type Work @default.
- W2040441424 sameAs 2040441424 @default.
- W2040441424 citedByCount "66" @default.
- W2040441424 countsByYear W20404414242012 @default.
- W2040441424 countsByYear W20404414242013 @default.
- W2040441424 countsByYear W20404414242014 @default.
- W2040441424 countsByYear W20404414242015 @default.
- W2040441424 countsByYear W20404414242016 @default.
- W2040441424 countsByYear W20404414242017 @default.
- W2040441424 countsByYear W20404414242018 @default.
- W2040441424 countsByYear W20404414242019 @default.
- W2040441424 countsByYear W20404414242020 @default.
- W2040441424 countsByYear W20404414242021 @default.
- W2040441424 countsByYear W20404414242022 @default.
- W2040441424 countsByYear W20404414242023 @default.
- W2040441424 crossrefType "journal-article" @default.
- W2040441424 hasAuthorship W2040441424A5013907641 @default.
- W2040441424 hasAuthorship W2040441424A5015943195 @default.
- W2040441424 hasAuthorship W2040441424A5016267462 @default.
- W2040441424 hasConcept C104317684 @default.
- W2040441424 hasConcept C134459356 @default.
- W2040441424 hasConcept C16525657 @default.
- W2040441424 hasConcept C171350616 @default.
- W2040441424 hasConcept C175114707 @default.
- W2040441424 hasConcept C181199279 @default.
- W2040441424 hasConcept C185592680 @default.
- W2040441424 hasConcept C25602115 @default.
- W2040441424 hasConcept C2779201268 @default.
- W2040441424 hasConcept C55493867 @default.
- W2040441424 hasConcept C86803240 @default.
- W2040441424 hasConcept C95444343 @default.
- W2040441424 hasConceptScore W2040441424C104317684 @default.
- W2040441424 hasConceptScore W2040441424C134459356 @default.
- W2040441424 hasConceptScore W2040441424C16525657 @default.
- W2040441424 hasConceptScore W2040441424C171350616 @default.
- W2040441424 hasConceptScore W2040441424C175114707 @default.
- W2040441424 hasConceptScore W2040441424C181199279 @default.
- W2040441424 hasConceptScore W2040441424C185592680 @default.
- W2040441424 hasConceptScore W2040441424C25602115 @default.
- W2040441424 hasConceptScore W2040441424C2779201268 @default.
- W2040441424 hasConceptScore W2040441424C55493867 @default.
- W2040441424 hasConceptScore W2040441424C86803240 @default.
- W2040441424 hasConceptScore W2040441424C95444343 @default.
- W2040441424 hasIssue "45" @default.
- W2040441424 hasLocation W20404414241 @default.
- W2040441424 hasLocation W20404414242 @default.
- W2040441424 hasOpenAccess W2040441424 @default.
- W2040441424 hasPrimaryLocation W20404414241 @default.
- W2040441424 hasRelatedWork W1964924844 @default.
- W2040441424 hasRelatedWork W1967480785 @default.
- W2040441424 hasRelatedWork W1990565865 @default.
- W2040441424 hasRelatedWork W1993349824 @default.
- W2040441424 hasRelatedWork W2017565084 @default.
- W2040441424 hasRelatedWork W2021044341 @default.
- W2040441424 hasRelatedWork W2047166991 @default.
- W2040441424 hasRelatedWork W2080485991 @default.
- W2040441424 hasRelatedWork W2751849239 @default.
- W2040441424 hasRelatedWork W2786239660 @default.
- W2040441424 hasVolume "45" @default.
- W2040441424 isParatext "false" @default.
- W2040441424 isRetracted "false" @default.
- W2040441424 magId "2040441424" @default.
- W2040441424 workType "article" @default.