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- W2040442651 abstract "New dithiane or dithiolane derivatives of gossypol and gossypolone were synthesized with dithiolethane or dithiolpropane in the presence of BF(3)/Et(2)O. These thioderivatives exhibited low toxicity on KB cells (human epidermoid carcinoma cells of the mouth). They react easily with electrophiles in aprotic solvents to regenerate gossypolone or to form dehydrogossypoldithianes and dehydrogossypoldithiolanes, which display higher toxicity on KB cells. In addition, the low toxicity of gossypol thioderivatives was reversed by nitric oxide donors in physiological media. These experiments suggest that gossypol and gossypolone dithianes and dithiolanes can be used as prodrugs that target tumor cells surrounded by high concentrations of nitric oxide." @default.
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- W2040442651 date "2003-05-01" @default.
- W2040442651 modified "2023-10-11" @default.
- W2040442651 title "New thioderivatives of gossypol and gossypolone, as prodrugs of cytotoxic agents" @default.
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- W2040442651 doi "https://doi.org/10.1016/s0968-0896(03)00066-x" @default.
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