FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040443012> ?p ?o ?g. }

• W2040443012 endingPage "1230" @default.
• W2040443012 startingPage "1217" @default.
• W2040443012 abstract "The central nervous system (CNS) is considered to be an immune-privileged site. For a long time, autoimmunity-induced inflammation has been viewed as an important mediator of secondary damage in the CNS following injury. However, other studies also suggest that autoimmunity is protective and beneficial. To investigate whether protective autoimmunity is present following spinal cord injury (SCI), we employed neonatally thymectomized (Tx) rats which contain few T lymphocytes in their peripheral blood, and passively immunized them with T lymphocytes activated by myelin basic protein (MBP) or spinal cord homogenate (SCH). Here we report that, among Tx, sham-Tx (sTx) and normal rats that received a contusive SCI, no significant histological and behavioral differences were found, suggesting that the endogenous T lymphocytes had no significant influence on the pathogenesis of secondary SCI. In rats passively immunized with MBP- or SCH-activated T cells (MBP-T or SCH-T, respectively), similar numbers of CD4+ T cells were found to infiltrate into the injured spinal cords. However, only the MBP-T immunization showed neuroprotection, evidenced by the reduction of post-traumatic neuronal losses and improvement of functional recovery. These results collectively suggest that not all T lymphocytes against CNS antigens are neuroprotective and that a subpopulation of them, such as those of MBP-T cells, could be beneficial for SCI repair." @default.
• W2040443012 created "2016-06-24" @default.
• W2040443012 creator A5005087327 @default.
• W2040443012 creator A5010097918 @default.
• W2040443012 creator A5025097212 @default.
• W2040443012 creator A5070200464 @default.
• W2040443012 creator A5073493427 @default.
• W2040443012 creator A5083918271 @default.
• W2040443012 creator A5091652696 @default.
• W2040443012 date "2008-11-01" @default.
• W2040443012 modified "2023-10-10" @default.
• W2040443012 title "Effects of autoimmunity on recovery of function in adult rats following spinal cord injury" @default.
• W2040443012 cites W1494722082 @default.
• W2040443012 cites W1547225066 @default.
• W2040443012 cites W1547955534 @default.
• W2040443012 cites W1625199767 @default.
• W2040443012 cites W1652473508 @default.
• W2040443012 cites W1963870368 @default.
• W2040443012 cites W1966805478 @default.
• W2040443012 cites W1969797231 @default.
• W2040443012 cites W1975970556 @default.
• W2040443012 cites W1983422527 @default.
• W2040443012 cites W1991746648 @default.
• W2040443012 cites W2000061964 @default.
• W2040443012 cites W2003995652 @default.
• W2040443012 cites W2011815863 @default.
• W2040443012 cites W2012028111 @default.
• W2040443012 cites W2013183815 @default.
• W2040443012 cites W2017605183 @default.
• W2040443012 cites W2020503077 @default.
• W2040443012 cites W2021385876 @default.
• W2040443012 cites W2023534353 @default.
• W2040443012 cites W2024877152 @default.
• W2040443012 cites W2031678720 @default.
• W2040443012 cites W2034197673 @default.
• W2040443012 cites W2037234762 @default.
• W2040443012 cites W2043087509 @default.
• W2040443012 cites W2045528880 @default.
• W2040443012 cites W2056579933 @default.
• W2040443012 cites W2064066068 @default.
• W2040443012 cites W2068646115 @default.
• W2040443012 cites W2077412377 @default.
• W2040443012 cites W2078156697 @default.
• W2040443012 cites W2081133235 @default.
• W2040443012 cites W2084099811 @default.
• W2040443012 cites W2085123429 @default.
• W2040443012 cites W2088449548 @default.
• W2040443012 cites W2093489232 @default.
• W2040443012 cites W2098734841 @default.
• W2040443012 cites W2101596476 @default.
• W2040443012 cites W2103583885 @default.
• W2040443012 cites W2113155599 @default.
• W2040443012 cites W2114947654 @default.
• W2040443012 cites W2115810336 @default.
• W2040443012 cites W2122662265 @default.
• W2040443012 cites W2122757851 @default.
• W2040443012 cites W2129704291 @default.
• W2040443012 cites W2130949787 @default.
• W2040443012 cites W2136716619 @default.
• W2040443012 cites W2141057018 @default.
• W2040443012 cites W2148255040 @default.
• W2040443012 cites W2149069297 @default.
• W2040443012 cites W2153463487 @default.
• W2040443012 cites W2154062809 @default.
• W2040443012 cites W2155516436 @default.
• W2040443012 cites W2155815888 @default.
• W2040443012 cites W2158863995 @default.
• W2040443012 cites W2164416677 @default.
• W2040443012 cites W2170645579 @default.
• W2040443012 cites W2615548860 @default.
• W2040443012 cites W4236005129 @default.
• W2040443012 cites W4313305941 @default.
• W2040443012 doi "https://doi.org/10.1016/j.bbi.2008.06.006" @default.
• W2040443012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18625299" @default.
• W2040443012 hasPublicationYear "2008" @default.
• W2040443012 type Work @default.
• W2040443012 sameAs 2040443012 @default.
• W2040443012 citedByCount "33" @default.
• W2040443012 countsByYear W20404430122012 @default.
• W2040443012 countsByYear W20404430122013 @default.
• W2040443012 countsByYear W20404430122014 @default.
• W2040443012 countsByYear W20404430122015 @default.
• W2040443012 countsByYear W20404430122016 @default.
• W2040443012 countsByYear W20404430122017 @default.
• W2040443012 countsByYear W20404430122018 @default.
• W2040443012 countsByYear W20404430122019 @default.
• W2040443012 countsByYear W20404430122020 @default.
• W2040443012 countsByYear W20404430122021 @default.
• W2040443012 countsByYear W20404430122023 @default.
• W2040443012 crossrefType "journal-article" @default.
• W2040443012 hasAuthorship W2040443012A5005087327 @default.
• W2040443012 hasAuthorship W2040443012A5010097918 @default.
• W2040443012 hasAuthorship W2040443012A5025097212 @default.
• W2040443012 hasAuthorship W2040443012A5070200464 @default.
• W2040443012 hasAuthorship W2040443012A5073493427 @default.
• W2040443012 hasAuthorship W2040443012A5083918271 @default.
• W2040443012 hasAuthorship W2040443012A5091652696 @default.
• W2040443012 hasConcept C118552586 @default.

• next