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- W2040444987 abstract "The morphology of influenza virions was found to depend on cellular determinants. Influenza viral filaments up to 30 μm in length were observed to form at high levels on surfaces of various polarized epithelial cell types infected with the A/Udorn/72 virus. In contrast, virions produced by nonpolarized cell types infected with this virus were almost exclusively of spherical morphology. Disruption of the actin microfilament array by cytochalasin D treatment of polarized MDCK cells had a profound effect on viral morphology. Although virus titers and release of spherical particles were not reduced in the presence of cytochalasin D, we observed a 15-fold reduction in the release of filamentous particles. In contrast, the ratio of filaments to spheres produced by infected MDCK cells was not altered by the microtubule-disrupting agent nocodazole. These observations indicate that the polarized cell phenotype and the integrity of the actin microfilament network are important cellular determinants of the morphology of a filamentous influenza virus." @default.
- W2040444987 created "2016-06-24" @default.
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- W2040444987 date "1998-05-12" @default.
- W2040444987 modified "2023-10-14" @default.
- W2040444987 title "Host cell dependence of viral morphology" @default.
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- W2040444987 doi "https://doi.org/10.1073/pnas.95.10.5746" @default.
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