Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040446048> ?p ?o ?g. }
- W2040446048 endingPage "20" @default.
- W2040446048 startingPage "11" @default.
- W2040446048 abstract "The tumor suppressor p53 controls a broad range of cellular responses. Induction of a transient (cell cycle arrest) or a permanent (senescence) block of cell proliferation, or the activation of cell death pathways in response to genotoxic stress comprise the major arms of the survival-death axis governed by p53. Due to these biological properties, inactivation of p53 is a crucial step in tumor development and progression, reflected by the high incidence of TP53 mutations in different types of human cancers. The remarkable potency of p53 in suppressing tumorigenic outgrowth has promoted the expectation that tumor cells expressing wild-type p53 (wtp53) should be more prone to elimination by cytotoxic treatments than tumor cells expressing mutant p53 (mutp53) with defunct wtp53 activities. However, recent findings yielded somewhat unexpected insights concerning the preponderance of the survival-promoting effects of wtp53 in cancer cells, a rather undesired property from the therapeutic point of view. In this commentary we will discuss the possibility that the developmentally established distinct patterns of wtp53 mediated responses in different tissues are an important factor in determining the ultimate outcome of cellular responses mediated by wtp53 in different types of tumor cells, with a particular focus on the divergent impact of wtp53 in malignant tumors of the central nervous system. We infer that a selective gain of pro-survival functions of wtp53 in cancer cells will confer a survival advantage that counteracts tumor therapy." @default.
- W2040446048 created "2016-06-24" @default.
- W2040446048 creator A5019233746 @default.
- W2040446048 creator A5046579926 @default.
- W2040446048 creator A5091514112 @default.
- W2040446048 date "2009-01-01" @default.
- W2040446048 modified "2023-10-01" @default.
- W2040446048 title "Wild-type p53 in cancer cells: When a guardian turns into a blackguard" @default.
- W2040446048 cites W14359987 @default.
- W2040446048 cites W1498528035 @default.
- W2040446048 cites W161352313 @default.
- W2040446048 cites W1650797637 @default.
- W2040446048 cites W1881393103 @default.
- W2040446048 cites W1964719993 @default.
- W2040446048 cites W1968601707 @default.
- W2040446048 cites W197014098 @default.
- W2040446048 cites W1972978471 @default.
- W2040446048 cites W1977108713 @default.
- W2040446048 cites W1978831014 @default.
- W2040446048 cites W1979386469 @default.
- W2040446048 cites W1979509218 @default.
- W2040446048 cites W1980614586 @default.
- W2040446048 cites W1982467220 @default.
- W2040446048 cites W1982545065 @default.
- W2040446048 cites W1984018823 @default.
- W2040446048 cites W1984885474 @default.
- W2040446048 cites W1994015824 @default.
- W2040446048 cites W1994852323 @default.
- W2040446048 cites W1996260588 @default.
- W2040446048 cites W1998530321 @default.
- W2040446048 cites W1999060423 @default.
- W2040446048 cites W2006405491 @default.
- W2040446048 cites W2008715871 @default.
- W2040446048 cites W2011824976 @default.
- W2040446048 cites W2012650432 @default.
- W2040446048 cites W2012714617 @default.
- W2040446048 cites W2014501359 @default.
- W2040446048 cites W2018070800 @default.
- W2040446048 cites W2018607339 @default.
- W2040446048 cites W2022395375 @default.
- W2040446048 cites W2022762967 @default.
- W2040446048 cites W2022811243 @default.
- W2040446048 cites W2024604828 @default.
- W2040446048 cites W2025476423 @default.
- W2040446048 cites W2025597700 @default.
- W2040446048 cites W2025977492 @default.
- W2040446048 cites W2031019010 @default.
- W2040446048 cites W2035066592 @default.
- W2040446048 cites W2035086650 @default.
- W2040446048 cites W2035462635 @default.
- W2040446048 cites W2036179093 @default.
- W2040446048 cites W2036270526 @default.
- W2040446048 cites W2039421163 @default.
- W2040446048 cites W2043985316 @default.
- W2040446048 cites W2045511809 @default.
- W2040446048 cites W2051945714 @default.
- W2040446048 cites W2052887017 @default.
- W2040446048 cites W2054264611 @default.
- W2040446048 cites W2055229861 @default.
- W2040446048 cites W2056079046 @default.
- W2040446048 cites W2060418052 @default.
- W2040446048 cites W2060551076 @default.
- W2040446048 cites W2060898340 @default.
- W2040446048 cites W2060929195 @default.
- W2040446048 cites W2061831020 @default.
- W2040446048 cites W2063823601 @default.
- W2040446048 cites W2064795157 @default.
- W2040446048 cites W2065214188 @default.
- W2040446048 cites W2066717966 @default.
- W2040446048 cites W2073788301 @default.
- W2040446048 cites W2074645889 @default.
- W2040446048 cites W2076668993 @default.
- W2040446048 cites W2082399676 @default.
- W2040446048 cites W2084104960 @default.
- W2040446048 cites W2085314493 @default.
- W2040446048 cites W2089482729 @default.
- W2040446048 cites W2089642386 @default.
- W2040446048 cites W2090216358 @default.
- W2040446048 cites W2090273457 @default.
- W2040446048 cites W2090834124 @default.
- W2040446048 cites W2093258581 @default.
- W2040446048 cites W2098493499 @default.
- W2040446048 cites W2100312975 @default.
- W2040446048 cites W2113724972 @default.
- W2040446048 cites W2123151929 @default.
- W2040446048 cites W2123509170 @default.
- W2040446048 cites W2124078079 @default.
- W2040446048 cites W2130555878 @default.
- W2040446048 cites W2132483998 @default.
- W2040446048 cites W2137446112 @default.
- W2040446048 cites W2147723796 @default.
- W2040446048 cites W2147751847 @default.
- W2040446048 cites W2150638747 @default.
- W2040446048 cites W2153172903 @default.
- W2040446048 cites W2154381385 @default.
- W2040446048 cites W2155570392 @default.
- W2040446048 cites W2159199900 @default.
- W2040446048 cites W2159849226 @default.