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• W2040448004 startingPage "468" @default.
• W2040448004 abstract "The cleavage of short chimeric oligonucleotides containing only one reactive ribonucleoside unit, all other nucleosides being 2'-O-methylated, has been studied at pH 8.5 and 35 degrees C. Among the 20 different sequences that did not exhibit any tendency to form a defined secondary structure, the scissile 5'-UpA-3' and 5'-CpA-3' phosphodiester bonds experienced >100- and up to 35-fold reactivity differences, respectively. Compared with dinucleoside monophosphates, both rate accelerations and retardations of more than one order of magnitude were observed. Even a change of a single base several nucleosides away from the scissile bond markedly affected the reaction rate. Duplex formation at the 3'- and/or 5'-side of the scissile bond was also studied and observed to be strongly rate retarding. The origin of the high sensitivity of phosphodiester bonds to the molecular environment is discussed." @default.
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• W2040448004 date "2002-01-15" @default.
• W2040448004 modified "2023-10-01" @default.
• W2040448004 title "The reactivity of phosphodiester bonds within linear single-stranded oligoribonucleotides is strongly dependent on the base sequence" @default.
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• W2040448004 doi "https://doi.org/10.1093/nar/30.2.468" @default.
• W2040448004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/99829" @default.
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