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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040453455> ?p ?o ?g. }

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• W2040453455 abstract "The gut-brain neuropeptide pituitary adenylate cyclase activating polypeptide (PACAP) is a novel highly conserved member of the secretin-glucagon-VIP peptide family comprising 38 or 27 amino acid residues. In this study, we investigate the actions of PACAP 1-27 or PACAP 1-38 on jejunal and caecal muscle strips from pig or guinea pig and demonstrate the neutralizing effect of two PACAP-specific monoclonal antibodies of the IgG1 subtype, RSP27II and RSP38. These antibodies were used to set up assay systems specific for PACAP 1-27 or PACAP 1-38. Monoclonal antibody RSP27II recognizes exclusively PACAP 1-27, whereas RSP38 binds only PACAP 1-38. PACAP 1-27 and PACAP 1-38 relax taenia caeci dose-dependently in the presence of guanethidine and scopolamine. Both peptides inhibit the spontaneous contractions of porcine jejunal muscle strips equipotently. Monoclonal antibodies RSP27II and RSP38 specifically neutralize the actions of either exogenously applied or endogenously released PACAP. Thus, they represent processing-specific tools to examine the physiological role of both molecular forms of PACAP in the gastrointestinal tract." @default.
• W2040453455 created "2016-06-24" @default.
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• W2040453455 date "1995-01-01" @default.
• W2040453455 modified "2023-09-26" @default.
• W2040453455 title "Specific monoclonal antibodies neutralize the action of PACAP 1–27 or PACAP 1–38 on intestinal muscle strips in vitro" @default.
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• W2040453455 doi "https://doi.org/10.1016/0167-0115(94)00092-c" @default.
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