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• W2040455320 startingPage "379" @default.
• W2040455320 abstract "Objective To estimate incidence and predictors of serious or life-threatening events that are not AIDS defining, AIDS events, and death among patients treated with highly active antiretroviral therapy (HAART) in the setting of 5 large multicenter randomized treatment trials conducted in the United States. Methods Data were analyzed from 2947 patients enrolled from December 1996 through December 2001. All patients were to receive antiretrovirals throughout follow-up. Data collection was uniform for all main outcome measures: serious or life-threatening (grade 4) events, AIDS, and death. Results During follow-up, 675 patients experienced a grade 4 event (11.4 per 100 person-years); 332 developed an AIDS event (5.6 per 100 person-years); and 272 died (4.6 per 100 person-years). The most common grade 4 events were liver related (148 patients, 2.6 per 100 person-years). Cardiovascular events were associated with the greatest risk of death (hazard ratio = 8.64; 95% CI: 5.1 to 14.5). The first grade 4 event and the first AIDS event were associated with similar risks of death, 5.68 and 6.95, respectively. Conclusions Grade 4 events are as important as AIDS events in the era of HAART. To adequately evaluate the impact of HAART on morbidity, comorbidities and other key factors must be carefully assessed." @default.
• W2040455320 created "2016-06-24" @default.
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• W2040455320 date "2003-12-01" @default.
• W2040455320 modified "2023-09-28" @default.
• W2040455320 title "Grade 4 Events Are as Important as AIDS Events in the Era of HAART" @default.
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• W2040455320 doi "https://doi.org/10.1097/00126334-200312010-00004" @default.
• W2040455320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14615655" @default.
• W2040455320 hasPublicationYear "2003" @default.
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