FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040457005> ?p ?o ?g. }

• W2040457005 endingPage "315" @default.
• W2040457005 startingPage "311" @default.
• W2040457005 abstract "The aim of this study was to investigate the methylation status of fragile histidine triad (FHIT) and the effects of FHIT on cell growth and cyclin D1 expression in hepatoma cells. The total proteins from the human hepatoma cell lines HepG2, Hep3B and Huh7 were collected and the expression levels of FHIT were analyzed. The methylation status in the promoter region of FHIT in the hepatoma cells was measured using methylation‑specific polymerase chain reaction (PCR). The HepG2, Hep3B and Huh7 cells were subsequently treated with 5‑aza-2'-deoxycytidine (5‑azadc) and the restoration of FHIT expression was then examined. A p‑hemagglutinin (HA)‑FHIT plasmid was constructed and used to transfect the HepG2 cells, and the inhibitory effects of the transfection on cell growth were then assessed. In addition, HepG2 cells were cotransfected with the pHA‑FHIT plasmid and a cyclin D1 luciferase reporter plasmid, and the effects of FHIT on the activity of cyclin D1 transcription factor were analyzed using a luciferase assay. FHIT was observed to be expressed at a low level in Hep3B and HepG2 cells; however, it was expressed at a relatively high level in Huh7 cells. The promoter region of FHIT in the Hep3B and HepG2 cells was partially methylated, and 5‑azadc treatment induced an increased expression of FHIT. The increased expression of FHIT inhibited the growth of HepG2 cells. Cotransfection with the pHA‑FHIT plasmid significantly inhibited the transcriptional activity of the cyclin D1 promoter and decreased the expression of cyclin D1 in HepG2 cells. In conclusion, FHIT was partially methylated in the HepG2 and Hep3B hepatoma cells. The overexpression of FHIT inhibited cell growth and decreased the expression of cyclin D1 in HepG2 cells." @default.
• W2040457005 created "2016-06-24" @default.
• W2040457005 creator A5020631350 @default.
• W2040457005 creator A5025189139 @default.
• W2040457005 creator A5031110020 @default.
• W2040457005 creator A5036298733 @default.
• W2040457005 creator A5046536990 @default.
• W2040457005 creator A5053275663 @default.
• W2040457005 creator A5089203400 @default.
• W2040457005 date "2013-12-04" @default.
• W2040457005 modified "2023-09-26" @default.
• W2040457005 title "FHIT overexpression in HepG2 hepatoma cells affects growth and cyclin D1 expression in vitro" @default.
• W2040457005 cites W1571094543 @default.
• W2040457005 cites W1579124614 @default.
• W2040457005 cites W1866912977 @default.
• W2040457005 cites W1867298697 @default.
• W2040457005 cites W1892327752 @default.
• W2040457005 cites W1970337657 @default.
• W2040457005 cites W2008581486 @default.
• W2040457005 cites W2037391515 @default.
• W2040457005 cites W2048756941 @default.
• W2040457005 cites W2057259362 @default.
• W2040457005 cites W2060440992 @default.
• W2040457005 cites W2061445402 @default.
• W2040457005 cites W2062353563 @default.
• W2040457005 cites W2084641677 @default.
• W2040457005 cites W2094010209 @default.
• W2040457005 cites W2094582492 @default.
• W2040457005 cites W2109811271 @default.
• W2040457005 cites W2110189793 @default.
• W2040457005 cites W2111552988 @default.
• W2040457005 cites W2112445375 @default.
• W2040457005 cites W2115053065 @default.
• W2040457005 cites W2135788727 @default.
• W2040457005 cites W2163900171 @default.
• W2040457005 cites W2305443941 @default.
• W2040457005 doi "https://doi.org/10.3892/etm.2013.1436" @default.
• W2040457005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3881045" @default.
• W2040457005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24396396" @default.
• W2040457005 hasPublicationYear "2013" @default.
• W2040457005 type Work @default.
• W2040457005 sameAs 2040457005 @default.
• W2040457005 citedByCount "0" @default.
• W2040457005 crossrefType "journal-article" @default.
• W2040457005 hasAuthorship W2040457005A5020631350 @default.
• W2040457005 hasAuthorship W2040457005A5025189139 @default.
• W2040457005 hasAuthorship W2040457005A5031110020 @default.
• W2040457005 hasAuthorship W2040457005A5036298733 @default.
• W2040457005 hasAuthorship W2040457005A5046536990 @default.
• W2040457005 hasAuthorship W2040457005A5053275663 @default.
• W2040457005 hasAuthorship W2040457005A5089203400 @default.
• W2040457005 hasBestOaLocation W20404570051 @default.
• W2040457005 hasConcept C104317684 @default.
• W2040457005 hasConcept C1491633281 @default.
• W2040457005 hasConcept C153911025 @default.
• W2040457005 hasConcept C185592680 @default.
• W2040457005 hasConcept C199835354 @default.
• W2040457005 hasConcept C2778264664 @default.
• W2040457005 hasConcept C2780646079 @default.
• W2040457005 hasConcept C29537977 @default.
• W2040457005 hasConcept C502942594 @default.
• W2040457005 hasConcept C54009773 @default.
• W2040457005 hasConcept C54355233 @default.
• W2040457005 hasConcept C555283112 @default.
• W2040457005 hasConcept C62112901 @default.
• W2040457005 hasConcept C81885089 @default.
• W2040457005 hasConcept C86803240 @default.
• W2040457005 hasConceptScore W2040457005C104317684 @default.
• W2040457005 hasConceptScore W2040457005C1491633281 @default.
• W2040457005 hasConceptScore W2040457005C153911025 @default.
• W2040457005 hasConceptScore W2040457005C185592680 @default.
• W2040457005 hasConceptScore W2040457005C199835354 @default.
• W2040457005 hasConceptScore W2040457005C2778264664 @default.
• W2040457005 hasConceptScore W2040457005C2780646079 @default.
• W2040457005 hasConceptScore W2040457005C29537977 @default.
• W2040457005 hasConceptScore W2040457005C502942594 @default.
• W2040457005 hasConceptScore W2040457005C54009773 @default.
• W2040457005 hasConceptScore W2040457005C54355233 @default.
• W2040457005 hasConceptScore W2040457005C555283112 @default.
• W2040457005 hasConceptScore W2040457005C62112901 @default.
• W2040457005 hasConceptScore W2040457005C81885089 @default.
• W2040457005 hasConceptScore W2040457005C86803240 @default.
• W2040457005 hasIssue "2" @default.
• W2040457005 hasLocation W20404570051 @default.
• W2040457005 hasLocation W20404570052 @default.
• W2040457005 hasLocation W20404570053 @default.
• W2040457005 hasLocation W20404570054 @default.
• W2040457005 hasOpenAccess W2040457005 @default.
• W2040457005 hasPrimaryLocation W20404570051 @default.
• W2040457005 hasRelatedWork W2066519212 @default.
• W2040457005 hasRelatedWork W2351812146 @default.
• W2040457005 hasRelatedWork W2355897695 @default.
• W2040457005 hasRelatedWork W2357329258 @default.
• W2040457005 hasRelatedWork W2365174857 @default.
• W2040457005 hasRelatedWork W2373495330 @default.
• W2040457005 hasRelatedWork W2374592133 @default.
• W2040457005 hasRelatedWork W2386243369 @default.
• W2040457005 hasRelatedWork W2387175565 @default.

• next