FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040459507> ?p ?o ?g. }

• W2040459507 endingPage "500" @default.
• W2040459507 startingPage "485" @default.
• W2040459507 abstract "A transgenic mouse containing the first exon of the human Huntington's disease (HD) gene has revealed a variety of behavioral and pathophysiological anomalies reminiscent of certain aspects of human Huntington's disease (HD). The present study has found that expression of the extracellular matrix glycoprotein tenascin-C appears to be unaffected in astroglial cells in wild-type and R6/2 transgenic mice that express the mutant huntingtin protein but that it is conspicuously absent in two neuronal populations within the cerebral cortex and thalamus of the R6/2 mice. Loss of tenascin-C expression begins between the fourth and eighth postnatal weeks, coincidental with the onset of abnormal behavioral phenotype and the appearance of intranuclear inclusion bodies and neuropil aggregates. By 12 weeks, R6/2 mice exhibit a complete absence of tenascin-C neuronal immunolabeling, a disappearance of cRNA probe-positive neurons across discrete cytoarchitectonic regions of the dorsal thalamus (e.g., the ventromedial, parafascicular, lateral posterior, and posterior thalamic groups) and frontal cortex, and an accompanying thalamic astrogliosis. The loss of neuronal tenascin-C expression includes structures that are known to send converging excitatory axonal projections to the caudate-putamen, the structure that is most at risk for neurodegeneration in HD. Altered neuronal expression of tenascin-C in R6/2 mice implicates altered transcriptional activities of the mutant huntingtin protein. The abnormal biochemistry and possibly abnormal activity of thalamostriate and corticostriate projection neurons may also affect abnormal neuronal activities in their primary connectional target, the neostriatum, which is severely compromised in HD. J. Comp. Neurol. 430:485–500, 2001. © 2001 Wiley-Liss, Inc." @default.
• W2040459507 created "2016-06-24" @default.
• W2040459507 creator A5006385979 @default.
• W2040459507 creator A5019233274 @default.
• W2040459507 creator A5020296130 @default.
• W2040459507 creator A5038978158 @default.
• W2040459507 creator A5045788593 @default.
• W2040459507 creator A5055251299 @default.
• W2040459507 creator A5057931396 @default.
• W2040459507 creator A5069602380 @default.
• W2040459507 date "2001-01-01" @default.
• W2040459507 modified "2023-09-27" @default.
• W2040459507 title "Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene" @default.
• W2040459507 cites W1486617476 @default.
• W2040459507 cites W1596467522 @default.
• W2040459507 cites W1622884348 @default.
• W2040459507 cites W1666764429 @default.
• W2040459507 cites W1905081238 @default.
• W2040459507 cites W1914270110 @default.
• W2040459507 cites W1962249623 @default.
• W2040459507 cites W1976555660 @default.
• W2040459507 cites W1977383752 @default.
• W2040459507 cites W1977831899 @default.
• W2040459507 cites W1985474993 @default.
• W2040459507 cites W1990406694 @default.
• W2040459507 cites W1997674775 @default.
• W2040459507 cites W1998974178 @default.
• W2040459507 cites W1999783230 @default.
• W2040459507 cites W2011084579 @default.
• W2040459507 cites W2011930181 @default.
• W2040459507 cites W2013029120 @default.
• W2040459507 cites W2013951424 @default.
• W2040459507 cites W2027126363 @default.
• W2040459507 cites W2031325850 @default.
• W2040459507 cites W2032255653 @default.
• W2040459507 cites W2038253384 @default.
• W2040459507 cites W2041922000 @default.
• W2040459507 cites W2042716629 @default.
• W2040459507 cites W2043899474 @default.
• W2040459507 cites W2048537234 @default.
• W2040459507 cites W2050453966 @default.
• W2040459507 cites W2058543711 @default.
• W2040459507 cites W2060588252 @default.
• W2040459507 cites W2062682951 @default.
• W2040459507 cites W2072396956 @default.
• W2040459507 cites W2080611727 @default.
• W2040459507 cites W2081870622 @default.
• W2040459507 cites W2082056883 @default.
• W2040459507 cites W2084639084 @default.
• W2040459507 cites W2084849755 @default.
• W2040459507 cites W2086914387 @default.
• W2040459507 cites W2087077651 @default.
• W2040459507 cites W2087258862 @default.
• W2040459507 cites W2090226055 @default.
• W2040459507 cites W2101411281 @default.
• W2040459507 cites W2103511872 @default.
• W2040459507 cites W2107522917 @default.
• W2040459507 cites W2108758429 @default.
• W2040459507 cites W2122440289 @default.
• W2040459507 cites W2135826703 @default.
• W2040459507 cites W2143315617 @default.
• W2040459507 cites W2146716740 @default.
• W2040459507 cites W2148937103 @default.
• W2040459507 cites W2149169654 @default.
• W2040459507 cites W2158786780 @default.
• W2040459507 cites W2168302341 @default.
• W2040459507 cites W2170453612 @default.
• W2040459507 cites W2170726804 @default.
• W2040459507 cites W2171705617 @default.
• W2040459507 cites W2180248710 @default.
• W2040459507 cites W4239583753 @default.
• W2040459507 doi "https://doi.org/10.1002/1096-9861(20010219)430:4<485::aid-cne1045>3.0.co;2-6" @default.
• W2040459507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11169482" @default.
• W2040459507 hasPublicationYear "2001" @default.
• W2040459507 type Work @default.
• W2040459507 sameAs 2040459507 @default.
• W2040459507 citedByCount "27" @default.
• W2040459507 countsByYear W20404595072012 @default.
• W2040459507 countsByYear W20404595072013 @default.
• W2040459507 countsByYear W20404595072014 @default.
• W2040459507 countsByYear W20404595072015 @default.
• W2040459507 countsByYear W20404595072016 @default.
• W2040459507 countsByYear W20404595072018 @default.
• W2040459507 countsByYear W20404595072022 @default.
• W2040459507 crossrefType "journal-article" @default.
• W2040459507 hasAuthorship W2040459507A5006385979 @default.
• W2040459507 hasAuthorship W2040459507A5019233274 @default.
• W2040459507 hasAuthorship W2040459507A5020296130 @default.
• W2040459507 hasAuthorship W2040459507A5038978158 @default.
• W2040459507 hasAuthorship W2040459507A5045788593 @default.
• W2040459507 hasAuthorship W2040459507A5055251299 @default.
• W2040459507 hasAuthorship W2040459507A5057931396 @default.
• W2040459507 hasAuthorship W2040459507A5069602380 @default.
• W2040459507 hasConcept C102230213 @default.
• W2040459507 hasConcept C104317684 @default.
• W2040459507 hasConcept C141035611 @default.
• W2040459507 hasConcept C142724271 @default.
• W2040459507 hasConcept C143065580 @default.

• next