FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040461249> ?p ?o ?g. }

• W2040461249 endingPage "82" @default.
• W2040461249 startingPage "71" @default.
• W2040461249 abstract "Hepatitis C virus (HCV) encodes for several proteins that can interfere with host cell signaling and antiviral response. Previously, serine protease NS3/4A was shown to block host cell interferon (IFN) production by proteolytic cleavage of MAVS and TRIF, the adaptor molecules of the RIG-I and TLR3 signaling pathways, respectively. This study shows that another HCV protease, NS2 can interfere efficiently with cytokine gene expression. NS2 and its proteolytically inactive mutant forms were able to inhibit type I and type III IFN, CCL5 and CXCL10 gene promoters activated by Sendai virus infection. However, the CXCL8 gene promoter was not inhibited by NS2. In addition, constitutively active RIG-I (ΔRIG-I), MAVS, TRIF, IKKε, and TBK1-induced activation of IFN-β promoter was inhibited by NS2. Cotransfection experiments with IKKε or TBK1 together with interferon regulatory factor 3 (IRF3) and HCV expression constructs revealed that NS2 in a dose-dependent manner inhibited IKKε and especially TBK1-induced IRF3 phosphorylation. GST pull-down experiments with GST-NS2 and in vitro-translated and cell-expressed IKKε and TBK1 demonstrated direct physical interactions of the kinases with NS2. Further evidence that the IKKε/TBK1 kinase complex is the target for NS2 was obtained from the observation that the constitutively active form of IRF3 (IRF3-5D) activated readily IFN-β promoter in the presence of NS2. The present study identified HCV NS2 as a potent interferon antagonist, and describes an explanation of how NS2 downregulates the major signaling pathways involved in the development of host innate antiviral responses. J. Med. Virol. 85:71–82, 2012. © 2012 Wiley Periodicals, Inc." @default.
• W2040461249 created "2016-06-24" @default.
• W2040461249 creator A5007995979 @default.
• W2040461249 creator A5011996258 @default.
• W2040461249 creator A5042449762 @default.
• W2040461249 creator A5067851120 @default.
• W2040461249 creator A5072762361 @default.
• W2040461249 date "2012-10-23" @default.
• W2040461249 modified "2023-09-27" @default.
• W2040461249 title "Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions" @default.
• W2040461249 cites W1965396914 @default.
• W2040461249 cites W1969728880 @default.
• W2040461249 cites W1971505503 @default.
• W2040461249 cites W1976209243 @default.
• W2040461249 cites W1980829155 @default.
• W2040461249 cites W2003778885 @default.
• W2040461249 cites W2012929232 @default.
• W2040461249 cites W2013092102 @default.
• W2040461249 cites W2013601771 @default.
• W2040461249 cites W2016825038 @default.
• W2040461249 cites W2018828712 @default.
• W2040461249 cites W2021199098 @default.
• W2040461249 cites W2023645777 @default.
• W2040461249 cites W2023923107 @default.
• W2040461249 cites W2028575270 @default.
• W2040461249 cites W2049115723 @default.
• W2040461249 cites W2050997685 @default.
• W2040461249 cites W2056504052 @default.
• W2040461249 cites W2059419113 @default.
• W2040461249 cites W2059919038 @default.
• W2040461249 cites W2063082801 @default.
• W2040461249 cites W2065554630 @default.
• W2040461249 cites W2076361525 @default.
• W2040461249 cites W2083631250 @default.
• W2040461249 cites W2084880831 @default.
• W2040461249 cites W2087395522 @default.
• W2040461249 cites W2089829321 @default.
• W2040461249 cites W2092454476 @default.
• W2040461249 cites W2093579074 @default.
• W2040461249 cites W2100107198 @default.
• W2040461249 cites W2100827617 @default.
• W2040461249 cites W2101525702 @default.
• W2040461249 cites W2105630217 @default.
• W2040461249 cites W2106132583 @default.
• W2040461249 cites W2107513655 @default.
• W2040461249 cites W2110217901 @default.
• W2040461249 cites W2112269300 @default.
• W2040461249 cites W2114913546 @default.
• W2040461249 cites W2118483041 @default.
• W2040461249 cites W2121284065 @default.
• W2040461249 cites W2137303998 @default.
• W2040461249 cites W2138401012 @default.
• W2040461249 cites W2141137217 @default.
• W2040461249 cites W2144787399 @default.
• W2040461249 cites W2144853224 @default.
• W2040461249 cites W2148387062 @default.
• W2040461249 cites W2148985310 @default.
• W2040461249 cites W2151581088 @default.
• W2040461249 cites W2154524244 @default.
• W2040461249 cites W2159803503 @default.
• W2040461249 cites W2171895134 @default.
• W2040461249 cites W4313306023 @default.
• W2040461249 doi "https://doi.org/10.1002/jmv.23442" @default.
• W2040461249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23096996" @default.
• W2040461249 hasPublicationYear "2012" @default.
• W2040461249 type Work @default.
• W2040461249 sameAs 2040461249 @default.
• W2040461249 citedByCount "44" @default.
• W2040461249 countsByYear W20404612492013 @default.
• W2040461249 countsByYear W20404612492014 @default.
• W2040461249 countsByYear W20404612492015 @default.
• W2040461249 countsByYear W20404612492016 @default.
• W2040461249 countsByYear W20404612492017 @default.
• W2040461249 countsByYear W20404612492018 @default.
• W2040461249 countsByYear W20404612492019 @default.
• W2040461249 countsByYear W20404612492021 @default.
• W2040461249 countsByYear W20404612492022 @default.
• W2040461249 crossrefType "journal-article" @default.
• W2040461249 hasAuthorship W2040461249A5007995979 @default.
• W2040461249 hasAuthorship W2040461249A5011996258 @default.
• W2040461249 hasAuthorship W2040461249A5042449762 @default.
• W2040461249 hasAuthorship W2040461249A5067851120 @default.
• W2040461249 hasAuthorship W2040461249A5072762361 @default.
• W2040461249 hasConcept C100175707 @default.
• W2040461249 hasConcept C11960822 @default.
• W2040461249 hasConcept C132379496 @default.
• W2040461249 hasConcept C136449434 @default.
• W2040461249 hasConcept C153911025 @default.
• W2040461249 hasConcept C156155473 @default.
• W2040461249 hasConcept C159047783 @default.
• W2040461249 hasConcept C170493617 @default.
• W2040461249 hasConcept C184235292 @default.
• W2040461249 hasConcept C2522874641 @default.
• W2040461249 hasConcept C2776178377 @default.
• W2040461249 hasConcept C2776408679 @default.
• W2040461249 hasConcept C2776709828 @default.
• W2040461249 hasConcept C2777730290 @default.
• W2040461249 hasConcept C2778420691 @default.

• next