FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040463710> ?p ?o ?g. }

• W2040463710 endingPage "206" @default.
• W2040463710 startingPage "198" @default.
• W2040463710 abstract "Sigma 1 receptors are associated with neurodegenerative and psychiatric disorders. These receptors, via their chaperoning functions that counteract endoplasmic reticulum stress and block neurodegeneration, may serve as a target for a new generation of antidepressants or neuroprotective agents. The involvement of these receptors has also been observed in neuropathic pain and cancer. Only a few ligands, such as Igmesine and Anavex 2-73, have been involved in clinical trials. Thus the development of sigma 1 ligands is of interest to a new generation of drugs. Previous work in our lab underlined the potency of benzannulated bicyclic compounds as interesting ligands. Herein the work was extended to a series of novel tricyclic compounds. Carboline- and phenothiazine-derivated compounds were designed and synthesized. In vitro competition binding assays for sigma 1 and 2 receptors showed that most of them have high affinity for sigma 1 receptor (Ki = 2.5-18 nM), and selectivity toward sigma 2 receptor, without cytotoxic effects on SY5Y cells." @default.
• W2040463710 created "2016-06-24" @default.
• W2040463710 creator A5046055163 @default.
• W2040463710 creator A5063781523 @default.
• W2040463710 creator A5073479024 @default.
• W2040463710 creator A5075828635 @default.
• W2040463710 creator A5087004045 @default.
• W2040463710 creator A5091590853 @default.
• W2040463710 date "2015-01-01" @default.
• W2040463710 modified "2023-10-17" @default.
• W2040463710 title "Carboline- and phenothiazine-derivated heterocycles as potent SIGMA-1 protein ligands" @default.
• W2040463710 cites W1965441070 @default.
• W2040463710 cites W1970653703 @default.
• W2040463710 cites W1974236532 @default.
• W2040463710 cites W1986595272 @default.
• W2040463710 cites W1990735183 @default.
• W2040463710 cites W1994224293 @default.
• W2040463710 cites W2000598080 @default.
• W2040463710 cites W2002642171 @default.
• W2040463710 cites W2019079031 @default.
• W2040463710 cites W2022577092 @default.
• W2040463710 cites W2027930394 @default.
• W2040463710 cites W2033760406 @default.
• W2040463710 cites W2041852417 @default.
• W2040463710 cites W2042804749 @default.
• W2040463710 cites W2060885983 @default.
• W2040463710 cites W2063990564 @default.
• W2040463710 cites W2066893357 @default.
• W2040463710 cites W2071737169 @default.
• W2040463710 cites W2074000839 @default.
• W2040463710 cites W2078786356 @default.
• W2040463710 cites W2088799477 @default.
• W2040463710 cites W2093330856 @default.
• W2040463710 cites W2119079146 @default.
• W2040463710 cites W2127287669 @default.
• W2040463710 cites W2131087015 @default.
• W2040463710 cites W2143538247 @default.
• W2040463710 cites W2156111928 @default.
• W2040463710 cites W2157285155 @default.
• W2040463710 cites W2318554523 @default.
• W2040463710 cites W2325390393 @default.
• W2040463710 cites W2950362638 @default.
• W2040463710 cites W4231446960 @default.
• W2040463710 cites W4241773780 @default.
• W2040463710 doi "https://doi.org/10.1016/j.ejmech.2014.10.053" @default.
• W2040463710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25462240" @default.
• W2040463710 hasPublicationYear "2015" @default.
• W2040463710 type Work @default.
• W2040463710 sameAs 2040463710 @default.
• W2040463710 citedByCount "17" @default.
• W2040463710 countsByYear W20404637102015 @default.
• W2040463710 countsByYear W20404637102016 @default.
• W2040463710 countsByYear W20404637102017 @default.
• W2040463710 countsByYear W20404637102018 @default.
• W2040463710 countsByYear W20404637102019 @default.
• W2040463710 countsByYear W20404637102020 @default.
• W2040463710 countsByYear W20404637102022 @default.
• W2040463710 countsByYear W20404637102023 @default.
• W2040463710 crossrefType "journal-article" @default.
• W2040463710 hasAuthorship W2040463710A5046055163 @default.
• W2040463710 hasAuthorship W2040463710A5063781523 @default.
• W2040463710 hasAuthorship W2040463710A5073479024 @default.
• W2040463710 hasAuthorship W2040463710A5075828635 @default.
• W2040463710 hasAuthorship W2040463710A5087004045 @default.
• W2040463710 hasAuthorship W2040463710A5091590853 @default.
• W2040463710 hasConcept C103133801 @default.
• W2040463710 hasConcept C170493617 @default.
• W2040463710 hasConcept C185592680 @default.
• W2040463710 hasConcept C202751555 @default.
• W2040463710 hasConcept C24961977 @default.
• W2040463710 hasConcept C25498285 @default.
• W2040463710 hasConcept C2777052854 @default.
• W2040463710 hasConcept C2778716775 @default.
• W2040463710 hasConcept C2778938600 @default.
• W2040463710 hasConcept C2781081902 @default.
• W2040463710 hasConcept C55493867 @default.
• W2040463710 hasConcept C71240020 @default.
• W2040463710 hasConcept C86803240 @default.
• W2040463710 hasConcept C98274493 @default.
• W2040463710 hasConceptScore W2040463710C103133801 @default.
• W2040463710 hasConceptScore W2040463710C170493617 @default.
• W2040463710 hasConceptScore W2040463710C185592680 @default.
• W2040463710 hasConceptScore W2040463710C202751555 @default.
• W2040463710 hasConceptScore W2040463710C24961977 @default.
• W2040463710 hasConceptScore W2040463710C25498285 @default.
• W2040463710 hasConceptScore W2040463710C2777052854 @default.
• W2040463710 hasConceptScore W2040463710C2778716775 @default.
• W2040463710 hasConceptScore W2040463710C2778938600 @default.
• W2040463710 hasConceptScore W2040463710C2781081902 @default.
• W2040463710 hasConceptScore W2040463710C55493867 @default.
• W2040463710 hasConceptScore W2040463710C71240020 @default.
• W2040463710 hasConceptScore W2040463710C86803240 @default.
• W2040463710 hasConceptScore W2040463710C98274493 @default.
• W2040463710 hasLocation W20404637101 @default.
• W2040463710 hasLocation W20404637102 @default.
• W2040463710 hasLocation W20404637103 @default.
• W2040463710 hasLocation W20404637104 @default.
• W2040463710 hasOpenAccess W2040463710 @default.

• next