Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040468807> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2040468807 endingPage "1213" @default.
- W2040468807 startingPage "1206" @default.
- W2040468807 abstract "Chimeric antigen receptors (CARs, immunoreceptors) are frequently used to redirect T cells with pre-defined specificity, in particular towards tumour cells for use in adoptive immunotherapy of malignant diseases. Specific targeting is mediated by an extracellularly located antibody-derived binding domain, which is joined to the transmembrane and intracellular CD3ζ moiety for T-cell activation. Stable CAR expression in T cells, however, requires a spacer domain interposed between the binding and the transmembrane domain and which is commonly the constant IgG1 Fc domain. We here revealed that CARs with Fc spacer domain bind to IgG Fc gamma receptors (FcγRs), thereby unintentionally activating innate immune cells, including monocytes and natural killer (NK) cells, which consequently secrete high amounts of pro-inflammatory cytokines. Engineered T cells, on the other hand, are likewise activated by FcγR binding resulting in cytokine secretion and lysis of monocytes and NK cells independently of the redirected specificity. To reduce FcγR binding, we modified the spacer domain without affecting CAR expression and antigen binding. Engineered with the modified CAR, T cells are not activated in presence of FcγR+ cells, thereby minimizing the risk of off-target activation while preserving their redirected targeting specificity." @default.
- W2040468807 created "2016-06-24" @default.
- W2040468807 creator A5023054875 @default.
- W2040468807 creator A5081176216 @default.
- W2040468807 date "2010-06-17" @default.
- W2040468807 modified "2023-10-05" @default.
- W2040468807 title "Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc ‘spacer’ domain in the extracellular moiety of chimeric antigen receptors avoids ‘off-target’ activation and unintended initiation of an innate immune response" @default.
- W2040468807 cites W126775936 @default.
- W2040468807 cites W141079059 @default.
- W2040468807 cites W1529809181 @default.
- W2040468807 cites W1965208881 @default.
- W2040468807 cites W1966496772 @default.
- W2040468807 cites W1981366087 @default.
- W2040468807 cites W2007509103 @default.
- W2040468807 cites W2011846490 @default.
- W2040468807 cites W2026462640 @default.
- W2040468807 cites W2029424132 @default.
- W2040468807 cites W2050302632 @default.
- W2040468807 cites W2061361662 @default.
- W2040468807 cites W2062932184 @default.
- W2040468807 cites W2064272625 @default.
- W2040468807 cites W2066938677 @default.
- W2040468807 cites W2067109042 @default.
- W2040468807 cites W2067650601 @default.
- W2040468807 cites W2068766896 @default.
- W2040468807 cites W2068890283 @default.
- W2040468807 cites W2136100686 @default.
- W2040468807 cites W2146702849 @default.
- W2040468807 doi "https://doi.org/10.1038/gt.2010.91" @default.
- W2040468807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20555360" @default.
- W2040468807 hasPublicationYear "2010" @default.
- W2040468807 type Work @default.
- W2040468807 sameAs 2040468807 @default.
- W2040468807 citedByCount "174" @default.
- W2040468807 countsByYear W20404688072012 @default.
- W2040468807 countsByYear W20404688072013 @default.
- W2040468807 countsByYear W20404688072014 @default.
- W2040468807 countsByYear W20404688072015 @default.
- W2040468807 countsByYear W20404688072016 @default.
- W2040468807 countsByYear W20404688072017 @default.
- W2040468807 countsByYear W20404688072018 @default.
- W2040468807 countsByYear W20404688072019 @default.
- W2040468807 countsByYear W20404688072020 @default.
- W2040468807 countsByYear W20404688072021 @default.
- W2040468807 countsByYear W20404688072022 @default.
- W2040468807 countsByYear W20404688072023 @default.
- W2040468807 crossrefType "journal-article" @default.
- W2040468807 hasAuthorship W2040468807A5023054875 @default.
- W2040468807 hasAuthorship W2040468807A5081176216 @default.
- W2040468807 hasBestOaLocation W20404688071 @default.
- W2040468807 hasConcept C136449434 @default.
- W2040468807 hasConcept C147483822 @default.
- W2040468807 hasConcept C153911025 @default.
- W2040468807 hasConcept C170493617 @default.
- W2040468807 hasConcept C203014093 @default.
- W2040468807 hasConcept C2776090121 @default.
- W2040468807 hasConcept C2777701055 @default.
- W2040468807 hasConcept C2780674031 @default.
- W2040468807 hasConcept C3875195 @default.
- W2040468807 hasConcept C55493867 @default.
- W2040468807 hasConcept C86803240 @default.
- W2040468807 hasConcept C8891405 @default.
- W2040468807 hasConcept C90375314 @default.
- W2040468807 hasConcept C95444343 @default.
- W2040468807 hasConceptScore W2040468807C136449434 @default.
- W2040468807 hasConceptScore W2040468807C147483822 @default.
- W2040468807 hasConceptScore W2040468807C153911025 @default.
- W2040468807 hasConceptScore W2040468807C170493617 @default.
- W2040468807 hasConceptScore W2040468807C203014093 @default.
- W2040468807 hasConceptScore W2040468807C2776090121 @default.
- W2040468807 hasConceptScore W2040468807C2777701055 @default.
- W2040468807 hasConceptScore W2040468807C2780674031 @default.
- W2040468807 hasConceptScore W2040468807C3875195 @default.
- W2040468807 hasConceptScore W2040468807C55493867 @default.
- W2040468807 hasConceptScore W2040468807C86803240 @default.
- W2040468807 hasConceptScore W2040468807C8891405 @default.
- W2040468807 hasConceptScore W2040468807C90375314 @default.
- W2040468807 hasConceptScore W2040468807C95444343 @default.
- W2040468807 hasIssue "10" @default.
- W2040468807 hasLocation W20404688071 @default.
- W2040468807 hasLocation W20404688072 @default.
- W2040468807 hasOpenAccess W2040468807 @default.
- W2040468807 hasPrimaryLocation W20404688071 @default.
- W2040468807 hasRelatedWork W1994960978 @default.
- W2040468807 hasRelatedWork W2006914724 @default.
- W2040468807 hasRelatedWork W2182307605 @default.
- W2040468807 hasRelatedWork W2910848452 @default.
- W2040468807 hasRelatedWork W2917396455 @default.
- W2040468807 hasRelatedWork W2955151930 @default.
- W2040468807 hasRelatedWork W3036523796 @default.
- W2040468807 hasRelatedWork W3126318561 @default.
- W2040468807 hasRelatedWork W3158325165 @default.
- W2040468807 hasRelatedWork W4372227954 @default.
- W2040468807 hasVolume "17" @default.
- W2040468807 isParatext "false" @default.
- W2040468807 isRetracted "false" @default.
- W2040468807 magId "2040468807" @default.
- W2040468807 workType "article" @default.