Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040473070> ?p ?o ?g. }
- W2040473070 endingPage "300" @default.
- W2040473070 startingPage "293" @default.
- W2040473070 abstract "Coexpression of platelet-derived growth factor (PDGF)-BB and activated PDGF-beta receptor in meningioma cells indicates that this cytokine may act as an autocrine or paracrine stimulant of meningioma growth. The intracellular events transducing signals from PDGF-beta receptor tyrosine kinases are unknown. In this study the authors evaluated whether or not mitogen-activated protein kinases (MAPKs) are expressed in meningiomas, regulate their growth, and transduce mitogenic signals of PDGF-BB.Ten human meningioma tumors as well as cells cultured from two normal leptomeninges and 10 additional human meningiomas were evaluated using Western blot analysis to determine the presence of MAPK and phosphorylated (activated) MAPK. The effects of PD098059, a selective inhibitor of MAPK phosphorylation/activation, on proliferation of meningioma cells stimulated with 10% fetal bovine serum was also evaluated. Last, the authors evaluated whether PDGF-BB stimulation of meningioma cells was associated with activation of MAPK. Western blots of lysates from meningiomas and from cultured leptomeningeal and meningioma cells demonstrated MAPK and phosphorylated MAPK. Treatment with PD098059 produced a 52 to 84% (x = 69.8) loss in [3H]thymidine incorporation, which was associated with a partial or complete loss of phosphorylated MAPK after 3 days of treatment. The PDGF-BB produced a significant increase in [3H]thymidine incorporation and phosphorylation of MAPK at 1 and 3 days. Coadministration of PD098059 completely blocked PDGF-BB's stimulation of [3H]thymidine incorporation and cell proliferation concomitant with reduced MAPK phosphorylation.The findings indicate that MAPK is constitutively expressed in leptomeningeal and meningioma cells and transduces mitogenic signals of PDGF, contributing to the growth of human meningiomas." @default.
- W2040473070 created "2016-06-24" @default.
- W2040473070 creator A5033605806 @default.
- W2040473070 creator A5043157842 @default.
- W2040473070 creator A5080630760 @default.
- W2040473070 creator A5085150194 @default.
- W2040473070 date "2001-02-01" @default.
- W2040473070 modified "2023-10-13" @default.
- W2040473070 title "Evidence for mitogen-associated protein kinase activation and transduction of mitogenic signals by platelet-derived growth factor in human meningioma cells" @default.
- W2040473070 cites W1491629634 @default.
- W2040473070 cites W1566737177 @default.
- W2040473070 cites W1742295292 @default.
- W2040473070 cites W1971915141 @default.
- W2040473070 cites W1990028805 @default.
- W2040473070 cites W1991613293 @default.
- W2040473070 cites W1999558229 @default.
- W2040473070 cites W2035936653 @default.
- W2040473070 cites W2042525806 @default.
- W2040473070 cites W2049128935 @default.
- W2040473070 cites W2052016477 @default.
- W2040473070 cites W2079348811 @default.
- W2040473070 cites W2079669698 @default.
- W2040473070 cites W2094249300 @default.
- W2040473070 cites W2160560563 @default.
- W2040473070 cites W38036891 @default.
- W2040473070 cites W4244698732 @default.
- W2040473070 cites W4292820908 @default.
- W2040473070 doi "https://doi.org/10.3171/jns.2001.94.2.0293" @default.
- W2040473070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11213968" @default.
- W2040473070 hasPublicationYear "2001" @default.
- W2040473070 type Work @default.
- W2040473070 sameAs 2040473070 @default.
- W2040473070 citedByCount "79" @default.
- W2040473070 countsByYear W20404730702012 @default.
- W2040473070 countsByYear W20404730702013 @default.
- W2040473070 countsByYear W20404730702014 @default.
- W2040473070 countsByYear W20404730702015 @default.
- W2040473070 countsByYear W20404730702016 @default.
- W2040473070 countsByYear W20404730702017 @default.
- W2040473070 countsByYear W20404730702018 @default.
- W2040473070 countsByYear W20404730702020 @default.
- W2040473070 countsByYear W20404730702021 @default.
- W2040473070 countsByYear W20404730702022 @default.
- W2040473070 countsByYear W20404730702023 @default.
- W2040473070 crossrefType "journal-article" @default.
- W2040473070 hasAuthorship W2040473070A5033605806 @default.
- W2040473070 hasAuthorship W2040473070A5043157842 @default.
- W2040473070 hasAuthorship W2040473070A5080630760 @default.
- W2040473070 hasAuthorship W2040473070A5085150194 @default.
- W2040473070 hasBestOaLocation W20404730701 @default.
- W2040473070 hasConcept C11960822 @default.
- W2040473070 hasConcept C126322002 @default.
- W2040473070 hasConcept C128240485 @default.
- W2040473070 hasConcept C132149769 @default.
- W2040473070 hasConcept C134018914 @default.
- W2040473070 hasConcept C153911025 @default.
- W2040473070 hasConcept C170493617 @default.
- W2040473070 hasConcept C180361614 @default.
- W2040473070 hasConcept C184235292 @default.
- W2040473070 hasConcept C2775960820 @default.
- W2040473070 hasConcept C2777553839 @default.
- W2040473070 hasConcept C2781249067 @default.
- W2040473070 hasConcept C2781294074 @default.
- W2040473070 hasConcept C502942594 @default.
- W2040473070 hasConcept C57074206 @default.
- W2040473070 hasConcept C71924100 @default.
- W2040473070 hasConcept C7876069 @default.
- W2040473070 hasConcept C86803240 @default.
- W2040473070 hasConcept C95444343 @default.
- W2040473070 hasConceptScore W2040473070C11960822 @default.
- W2040473070 hasConceptScore W2040473070C126322002 @default.
- W2040473070 hasConceptScore W2040473070C128240485 @default.
- W2040473070 hasConceptScore W2040473070C132149769 @default.
- W2040473070 hasConceptScore W2040473070C134018914 @default.
- W2040473070 hasConceptScore W2040473070C153911025 @default.
- W2040473070 hasConceptScore W2040473070C170493617 @default.
- W2040473070 hasConceptScore W2040473070C180361614 @default.
- W2040473070 hasConceptScore W2040473070C184235292 @default.
- W2040473070 hasConceptScore W2040473070C2775960820 @default.
- W2040473070 hasConceptScore W2040473070C2777553839 @default.
- W2040473070 hasConceptScore W2040473070C2781249067 @default.
- W2040473070 hasConceptScore W2040473070C2781294074 @default.
- W2040473070 hasConceptScore W2040473070C502942594 @default.
- W2040473070 hasConceptScore W2040473070C57074206 @default.
- W2040473070 hasConceptScore W2040473070C71924100 @default.
- W2040473070 hasConceptScore W2040473070C7876069 @default.
- W2040473070 hasConceptScore W2040473070C86803240 @default.
- W2040473070 hasConceptScore W2040473070C95444343 @default.
- W2040473070 hasIssue "2" @default.
- W2040473070 hasLocation W20404730701 @default.
- W2040473070 hasLocation W20404730702 @default.
- W2040473070 hasOpenAccess W2040473070 @default.
- W2040473070 hasPrimaryLocation W20404730701 @default.
- W2040473070 hasRelatedWork W19813757 @default.
- W2040473070 hasRelatedWork W1993452556 @default.
- W2040473070 hasRelatedWork W2085463220 @default.
- W2040473070 hasRelatedWork W2094249300 @default.
- W2040473070 hasRelatedWork W2268933405 @default.