FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040474290> ?p ?o ?g. }

• W2040474290 endingPage "1051" @default.
• W2040474290 startingPage "1043" @default.
• W2040474290 abstract "There is increasing evidence that neuropeptide Y (NPY) affects the release of pituitary hormones, including adrenocorticotropic hormone (ACTH). The present study was designed to clarify the mechanism by which NPY activates the hypothalamic-pituitary-adrenal (HPA) axis in the dog. Mongrel dogs were equipped with a chronic cannula allowing intra-third (i.t.v.) or intra-lateral (i.l.v.) cerebroventricular administration. A 1.19 nmol, i.t.v. dose of NPY produced as great an ACTH and cortisol response as did equimolar ovine corticotropin releasing factor (CRF). This action of NPY was dose-dependent and shared by peptide YY (PYY) and pancreatic polypeptide (PP), other members of the PP family peptide. Intravenously (i.v.) administered NPY (1.19-11.9 nmol) was much less potent than i.v. CRF in stimulating ACTH and cortisol secretion. However, i.v. NPY significantly increased plasma ACTH and cortisol concentrations, raising the possibility that NPY may modulate the activity of corticotrophs. We have next investigated the possible relationship between NPY and CRF on the HPA axis. Pretreatment with a novel CRF antagonist, alpha-helical CRF9-41 (130.9 nmol i.t.v. or 261.8 nmol i.v.), partly but significantly attenuated the ACTH and cortisol responses to i.t.v. NPY (1.19 nmol). Furthermore, adding a subthreshold dose of i.t.v. NPY (0.119 nmol) to i.t.v. CRF (1.19 nmol) or i.v. NPY (2.38 nmol) to i.v. CRF (0.595 nmol) resulted in the potentiation of CRF-induced ACTH secretion. These results indicate that NPY may activate the HPA axis in concert with CRF probably at hypothalamic and/or pituitary levels. The present findings that NPY evokes ACTH secretion and potentiates the effectiveness of CRF as a secretagogue, together with high concentrations of NPY in the hypothalamus and pituitary portal blood, suggest that NPY is involved in the multihormonal control of ACTH release." @default.
• W2040474290 created "2016-06-24" @default.
• W2040474290 creator A5005313594 @default.
• W2040474290 creator A5005418729 @default.
• W2040474290 creator A5006783107 @default.
• W2040474290 creator A5010897454 @default.
• W2040474290 creator A5011798844 @default.
• W2040474290 creator A5022604285 @default.
• W2040474290 creator A5025211329 @default.
• W2040474290 creator A5049690579 @default.
• W2040474290 creator A5076967471 @default.
• W2040474290 date "1989-01-01" @default.
• W2040474290 modified "2023-09-27" @default.
• W2040474290 title "Effect of neuropeptide Y on the hypothalamic-pituitary-adrenal axis in the dog" @default.
• W2040474290 cites W1967744740 @default.
• W2040474290 cites W1975815034 @default.
• W2040474290 cites W1980780685 @default.
• W2040474290 cites W1991123973 @default.
• W2040474290 cites W1993866430 @default.
• W2040474290 cites W2007903907 @default.
• W2040474290 cites W2011274949 @default.
• W2040474290 cites W2014400191 @default.
• W2040474290 cites W2026136209 @default.
• W2040474290 cites W2028953214 @default.
• W2040474290 cites W2031463222 @default.
• W2040474290 cites W2031850503 @default.
• W2040474290 cites W2032725109 @default.
• W2040474290 cites W2036216347 @default.
• W2040474290 cites W2038411879 @default.
• W2040474290 cites W2039020023 @default.
• W2040474290 cites W2040329579 @default.
• W2040474290 cites W2041315809 @default.
• W2040474290 cites W2046628195 @default.
• W2040474290 cites W2053807193 @default.
• W2040474290 cites W2058306762 @default.
• W2040474290 cites W2059246703 @default.
• W2040474290 cites W2060152059 @default.
• W2040474290 cites W2061156895 @default.
• W2040474290 cites W2064110992 @default.
• W2040474290 cites W2080669000 @default.
• W2040474290 cites W2085955084 @default.
• W2040474290 cites W2088269503 @default.
• W2040474290 cites W2090814796 @default.
• W2040474290 cites W2094283169 @default.
• W2040474290 cites W2095036452 @default.
• W2040474290 cites W2114608871 @default.
• W2040474290 cites W2145128242 @default.
• W2040474290 cites W2175087497 @default.
• W2040474290 cites W4376848280 @default.
• W2040474290 doi "https://doi.org/10.1016/0024-3205(89)90556-0" @default.
• W2040474290 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2538698" @default.
• W2040474290 hasPublicationYear "1989" @default.
• W2040474290 type Work @default.
• W2040474290 sameAs 2040474290 @default.
• W2040474290 citedByCount "51" @default.
• W2040474290 countsByYear W20404742902014 @default.
• W2040474290 countsByYear W20404742902017 @default.
• W2040474290 countsByYear W20404742902019 @default.
• W2040474290 countsByYear W20404742902022 @default.
• W2040474290 countsByYear W20404742902023 @default.
• W2040474290 crossrefType "journal-article" @default.
• W2040474290 hasAuthorship W2040474290A5005313594 @default.
• W2040474290 hasAuthorship W2040474290A5005418729 @default.
• W2040474290 hasAuthorship W2040474290A5006783107 @default.
• W2040474290 hasAuthorship W2040474290A5010897454 @default.
• W2040474290 hasAuthorship W2040474290A5011798844 @default.
• W2040474290 hasAuthorship W2040474290A5022604285 @default.
• W2040474290 hasAuthorship W2040474290A5025211329 @default.
• W2040474290 hasAuthorship W2040474290A5049690579 @default.
• W2040474290 hasAuthorship W2040474290A5076967471 @default.
• W2040474290 hasConcept C118303440 @default.
• W2040474290 hasConcept C126322002 @default.
• W2040474290 hasConcept C134018914 @default.
• W2040474290 hasConcept C170493617 @default.
• W2040474290 hasConcept C185592680 @default.
• W2040474290 hasConcept C2778108375 @default.
• W2040474290 hasConcept C2778458438 @default.
• W2040474290 hasConcept C2778563252 @default.
• W2040474290 hasConcept C2779029589 @default.
• W2040474290 hasConcept C2780546910 @default.
• W2040474290 hasConcept C2909643783 @default.
• W2040474290 hasConcept C56191518 @default.
• W2040474290 hasConcept C71315377 @default.
• W2040474290 hasConcept C71924100 @default.
• W2040474290 hasConcept C79381400 @default.
• W2040474290 hasConcept C93984277 @default.
• W2040474290 hasConceptScore W2040474290C118303440 @default.
• W2040474290 hasConceptScore W2040474290C126322002 @default.
• W2040474290 hasConceptScore W2040474290C134018914 @default.
• W2040474290 hasConceptScore W2040474290C170493617 @default.
• W2040474290 hasConceptScore W2040474290C185592680 @default.
• W2040474290 hasConceptScore W2040474290C2778108375 @default.
• W2040474290 hasConceptScore W2040474290C2778458438 @default.
• W2040474290 hasConceptScore W2040474290C2778563252 @default.
• W2040474290 hasConceptScore W2040474290C2779029589 @default.
• W2040474290 hasConceptScore W2040474290C2780546910 @default.
• W2040474290 hasConceptScore W2040474290C2909643783 @default.
• W2040474290 hasConceptScore W2040474290C56191518 @default.

• next