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• W2040477625 abstract "To investigate if genomic instability exists in tumors with cytogenetically normal karyotypes, we analyzed four diploid cancer cell lines A204, CAL51, CH1 and SK-UT-1B. We detected subtle genomic changes in all four cell lines. More of these alterations were found in A204 and CH1 than in the microsatellite unstable lines CAL51 and SK-UT-1B. The number of de novo, non-clonal chromosome rearrangements was also significantly higher in CH1 than CAL51 and SK-UT-1B (p=0.001). This study reveals multiple genomic abnormalities in tumors with near normal karyotypes and suggests that genomic instability may be essential in cancer development." @default.
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• W2040477625 date "2008-08-01" @default.
• W2040477625 modified "2023-10-16" @default.
• W2040477625 title "Subtle genomic alterations and genomic instability revealed in diploid cancer cell lines" @default.
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• W2040477625 doi "https://doi.org/10.1016/j.canlet.2008.03.003" @default.
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