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- W2040477989 abstract "Previous studies have shown that women with poor ovarian response have a higher risk of miscarriage following IVF treatment. The aim of this study was to determine whether excess miscarriages seen in women with poor ovarian response are more likely to be aneuploid than miscarriages among normal responders. Retrospective review of miscarriages with known karyotype after an IVF conception between 2002-2013. A total of 265 miscarriages were identified. IVF cycles utilizing donor eggs or PGD were excluded. Patients were divided into two groups, those with 6 or fewer oocytes retrieved, and those with more than 6. The proportion of aneuploid losses was compared between the groups using χ2-squared testing. Logistic regression analysis was also performed.Table 1Egg Number≤6 (73 total)>6 (192 total)P-valueMaternal age mean (SD)39.5 (3.62)36.11 (4.4)<0.001Oocyte number mean (SD)4.36 (1.45)16.26 (6.55)<0.001% ICSI51%49%0.801% Day 3 transfers92%47%<0.001% Frozen transfers4%21%0.001% Aneuploid78%60%0.006 Open table in a new tab Patients with 6 or fewer eggs were significantly more likely to have aneuploid losses (p=0.006) than those with more than 6 eggs. Logistic regression analysis of egg number alone as a predictor of aneuploidy also demonstrated a significant association (p=0.017). However, further analysis controlling for age failed to demonstrate significance (p=0.137). Low egg number at initial retrieval was associated with higher aneuploidy rate in miscarriages, which is likely due to differences in maternal age. However, an age-independent association between low egg number and a higher miscarriage rate has been previously reported. Additional studies are needed in order to determine whether egg number is an age-independent predictor of aneuploidy." @default.
- W2040477989 created "2016-06-24" @default.
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- W2040477989 date "2013-09-01" @default.
- W2040477989 modified "2023-09-30" @default.
- W2040477989 title "Risk of aneuploidy in miscarriages after IVF is associated with low oocyte yield" @default.
- W2040477989 doi "https://doi.org/10.1016/j.fertnstert.2013.07.998" @default.
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