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- W2040478918 endingPage "2085" @default.
- W2040478918 startingPage "2071" @default.
- W2040478918 abstract "Sex-specific alternative processing of the doublesex (dsx) pre-mRNA controls somatic sexual differentiation in Drosophila melanogaster. Processing in the female-specific pattern results from the utilization of an upstream 3'-terminal exon and requires the activities of both the transformer (tra) and transformer-2 (tra-2) genes. Use of the more downstream male-specific terminal exons does not require the activities of these genes and is thus considered the default dsx-processing pattern. Here, we used transient expression of dsx pre-mRNAs in the presence or absence of tra and tra-2 gene products in Drosophila tissue culture cells to investigate the molecular mechanism controlling this alternative RNA-processing decision. These studies reveal that female-specific processing of dsx pre-mRNA is controlled by tra and tra-2 through the positive regulation of female-specific alternative 3'-terminal exon use. Delineation of cis-acting sequences necessary for regulation shows that a 540-nucleotide region from within the female exon is both necessary and sufficient for regulation. In addition, utilization of the female-specific 3'-splice site (3'SS) is regulated independently of female-specific polyadenylation. Regulated polyadenylation was obtained only in the presence of splicing, suggesting that activation of female-specific exon use occurs by 3'SS activation." @default.
- W2040478918 created "2016-06-24" @default.
- W2040478918 creator A5006940807 @default.
- W2040478918 creator A5063237025 @default.
- W2040478918 date "1991-11-01" @default.
- W2040478918 modified "2023-10-15" @default.
- W2040478918 title "Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation." @default.
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- W2040478918 doi "https://doi.org/10.1101/gad.5.11.2071" @default.
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