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- W2040479725 abstract "Platelet aggregation plays a central role in the ischemic complications of percutaneous coronary interventions (PCI) and the acute coronary syndromes (ACS). Although aspirin and heparin have been effective at decreasing adverse events in these settings, the perceived need for more potent inhibition of platelet aggregation has led to targeting of the platelet surface membrane glycoprotein IIb/IIIa (GP IIb/IIIa) receptor. Several agents have been developed; four: abciximab, tirofiban, eptifibatide, and lamifiban have been tested in clinical trials. Overall, the positive findings of these studies have supported the hypothesis that enhanced platelet blockade leads to improved clinical outcomes in the settings of PCI and ACS. In this article, an overview of the various GP IIb/IIIa receptor inhibitors is presented. The clinical trials of these agents as adjunctive therapy for patients undergoing PCI and in treatment of acute myocardial infarction are reviewed. Practical considerations relating to clinical efficacy, drug safety, and economic issues are discussed." @default.
- W2040479725 created "2016-06-24" @default.
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- W2040479725 date "1998-10-01" @default.
- W2040479725 modified "2023-09-28" @default.
- W2040479725 title "Update on Glycoprotein IIb/IIIa Blockade in Endovascular Interventions" @default.
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- W2040479725 doi "https://doi.org/10.1111/j.1540-8183.1998.tb00184.x" @default.
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