FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040483531> ?p ?o ?g. }

• W2040483531 endingPage "7500" @default.
• W2040483531 startingPage "7496" @default.
• W2040483531 abstract "We have discovered that N-acetyl-L-cysteine (NAC) protects cells against death induced by exposure to noxious stimuli and against programmed cell death (apoptosis) associated with exposure to inadequate amounts of trophic factors. NAC prevented glutamate-induced death of oligodendrocytes and tumor necrosis factor alpha (TNF-alpha)-induced death of oligodendrocytes and L929 fibroblasts. Moreover, suboptimal doses of NAC plus ciliary neurotrophic factor (which also protects oligodendrocytes against TNF-alpha-mediated killing) acted synergistically to protect oligodendrocytes against TNF-alpha-induced death. Protection against death by growth factor deprivation was provided by the combination of (i) NAC, vitamin C, or Trolox (a water-soluble analogue of vitamin E) with suboptimal concentrations of protein trophic factors, (ii) NAC, vitamin C, or Trolox with progesterone, and (iii) NAC with either vitamin C or Trolox; these latter experiments suggest that the addition of tyrosine kinase stimulators is not required to promote cell survival. In all paradigms, NAC was either equally or more effective than the other compounds examined. In light of the long history of therapeutic application of NAC, we suggest that use of this compound may be of interest in conditions where certain toxin-mediated forms of cell death and/or apoptosis contribute significantly to disease." @default.
• W2040483531 created "2016-06-24" @default.
• W2040483531 creator A5003815469 @default.
• W2040483531 creator A5047718669 @default.
• W2040483531 date "1994-08-02" @default.
• W2040483531 modified "2023-09-24" @default.
• W2040483531 title "N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro." @default.
• W2040483531 cites W1506034405 @default.
• W2040483531 cites W1554708598 @default.
• W2040483531 cites W1564843449 @default.
• W2040483531 cites W1583483795 @default.
• W2040483531 cites W1589415602 @default.
• W2040483531 cites W1637626362 @default.
• W2040483531 cites W1966242116 @default.
• W2040483531 cites W1969535697 @default.
• W2040483531 cites W1972524334 @default.
• W2040483531 cites W1981881657 @default.
• W2040483531 cites W1982784171 @default.
• W2040483531 cites W1987885030 @default.
• W2040483531 cites W1995317658 @default.
• W2040483531 cites W1998225973 @default.
• W2040483531 cites W2004219852 @default.
• W2040483531 cites W2006162058 @default.
• W2040483531 cites W2006593236 @default.
• W2040483531 cites W2007064404 @default.
• W2040483531 cites W2012744796 @default.
• W2040483531 cites W2020333978 @default.
• W2040483531 cites W2022787401 @default.
• W2040483531 cites W2025203545 @default.
• W2040483531 cites W2030733295 @default.
• W2040483531 cites W2031468048 @default.
• W2040483531 cites W2033939933 @default.
• W2040483531 cites W2036567890 @default.
• W2040483531 cites W2038282704 @default.
• W2040483531 cites W2048158801 @default.
• W2040483531 cites W2056958245 @default.
• W2040483531 cites W2069333165 @default.
• W2040483531 cites W2074558188 @default.
• W2040483531 cites W2081560586 @default.
• W2040483531 cites W2084331126 @default.
• W2040483531 cites W2088509118 @default.
• W2040483531 cites W2088696081 @default.
• W2040483531 cites W2092683047 @default.
• W2040483531 cites W2097939870 @default.
• W2040483531 cites W2114918609 @default.
• W2040483531 cites W2132963869 @default.
• W2040483531 cites W2150929583 @default.
• W2040483531 cites W2165278466 @default.
• W2040483531 cites W2267370441 @default.
• W2040483531 cites W2324196113 @default.
• W2040483531 cites W2333107025 @default.
• W2040483531 cites W4229792731 @default.
• W2040483531 cites W4245957869 @default.
• W2040483531 doi "https://doi.org/10.1073/pnas.91.16.7496" @default.
• W2040483531 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44428" @default.
• W2040483531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7914368" @default.
• W2040483531 hasPublicationYear "1994" @default.
• W2040483531 type Work @default.
• W2040483531 sameAs 2040483531 @default.
• W2040483531 citedByCount "352" @default.
• W2040483531 countsByYear W20404835312012 @default.
• W2040483531 countsByYear W20404835312013 @default.
• W2040483531 countsByYear W20404835312014 @default.
• W2040483531 countsByYear W20404835312015 @default.
• W2040483531 countsByYear W20404835312016 @default.
• W2040483531 countsByYear W20404835312017 @default.
• W2040483531 countsByYear W20404835312018 @default.
• W2040483531 countsByYear W20404835312019 @default.
• W2040483531 countsByYear W20404835312020 @default.
• W2040483531 countsByYear W20404835312021 @default.
• W2040483531 countsByYear W20404835312022 @default.
• W2040483531 countsByYear W20404835312023 @default.
• W2040483531 crossrefType "journal-article" @default.
• W2040483531 hasAuthorship W2040483531A5003815469 @default.
• W2040483531 hasAuthorship W2040483531A5047718669 @default.
• W2040483531 hasBestOaLocation W20404835311 @default.
• W2040483531 hasConcept C160539049 @default.
• W2040483531 hasConcept C170493617 @default.
• W2040483531 hasConcept C17991360 @default.
• W2040483531 hasConcept C190283241 @default.
• W2040483531 hasConcept C203014093 @default.
• W2040483531 hasConcept C2776151105 @default.
• W2040483531 hasConcept C2776231299 @default.
• W2040483531 hasConcept C2993539680 @default.
• W2040483531 hasConcept C31573885 @default.
• W2040483531 hasConcept C55493867 @default.
• W2040483531 hasConcept C68710172 @default.
• W2040483531 hasConcept C86803240 @default.
• W2040483531 hasConcept C95444343 @default.
• W2040483531 hasConcept C98274493 @default.
• W2040483531 hasConceptScore W2040483531C160539049 @default.
• W2040483531 hasConceptScore W2040483531C170493617 @default.
• W2040483531 hasConceptScore W2040483531C17991360 @default.
• W2040483531 hasConceptScore W2040483531C190283241 @default.
• W2040483531 hasConceptScore W2040483531C203014093 @default.
• W2040483531 hasConceptScore W2040483531C2776151105 @default.
• W2040483531 hasConceptScore W2040483531C2776231299 @default.
• W2040483531 hasConceptScore W2040483531C2993539680 @default.

• next