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• W2040483936 endingPage "442" @default.
• W2040483936 startingPage "434" @default.
• W2040483936 abstract "T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of thymocytes affecting preferentially children and adolescents. The disease is heterogeneous and characterized by a large set of chromosomal and genetic alterations that deregulate the growth of maturing thymocytes. The identification of activating point mutations in NOTCH1 in more then 50% of all T-ALL cases highlights the NOTCH1 cascade as a central player of T-ALL pathogenesis. In this review, we summarize and update more recent findings on the molecular mechanisms of T-ALL with a particular emphasis on the oncogenic properties of aberrant NOTCH1 signaling." @default.
• W2040483936 created "2016-06-24" @default.
• W2040483936 creator A5061774460 @default.
• W2040483936 creator A5083292682 @default.
• W2040483936 date "2011-09-01" @default.
• W2040483936 modified "2023-10-16" @default.
• W2040483936 title "Notch in T-ALL: new players in a complex disease" @default.
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• W2040483936 doi "https://doi.org/10.1016/j.it.2011.06.005" @default.
• W2040483936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21775206" @default.
• W2040483936 hasPublicationYear "2011" @default.
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