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• W2040484651 endingPage "246" @default.
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• W2040484651 abstract "•Changes in gene expression in the CNS are associated with chronic pain. •Epigenetic mechanisms modulate long-term changes in gene expression. •Epigenetic activity correlates with behavioral manifestations of chronic pain. •Targeting epigenetic pathways alters behavioral and molecular markers of pain. •Focus on epigenetics may help reveal novel therapeutic targets for chronic pain. Neuropathic and inflammatory pain promote a large number of persisting adaptations at the cellular and molecular level, allowing even transient tissue or nerve damage to elicit changes in cells that contribute to the development of chronic pain and associated symptoms. There is evidence that injury-induced changes in chromatin structure drive stable changes in gene expression and neural function, which may cause several symptoms, including allodynia, hyperalgesia, anxiety, and depression. Recent findings on epigenetic changes in the spinal cord and brain during chronic pain may guide fundamental advances in new treatments. Here, we provide a brief overview of epigenetic regulation in the nervous system and then discuss the still-limited literature that directly implicates epigenetic modifications in chronic pain syndromes. Neuropathic and inflammatory pain promote a large number of persisting adaptations at the cellular and molecular level, allowing even transient tissue or nerve damage to elicit changes in cells that contribute to the development of chronic pain and associated symptoms. There is evidence that injury-induced changes in chromatin structure drive stable changes in gene expression and neural function, which may cause several symptoms, including allodynia, hyperalgesia, anxiety, and depression. Recent findings on epigenetic changes in the spinal cord and brain during chronic pain may guide fundamental advances in new treatments. Here, we provide a brief overview of epigenetic regulation in the nervous system and then discuss the still-limited literature that directly implicates epigenetic modifications in chronic pain syndromes. Erratum: Epigenetic mechanisms of chronic pain: [Trends in Neurosciences 38 (2015), 237-246]Descalzi et al.Trends in NeurosciencesAugust 6, 2015In BriefIn this article several abbreviations were incorrect. At all locations in the first paragraph on p. 243 “miR-249” should read “miR-429”. Similarly, in the table on p. 244 under the sixth entry “miR-249” should read “miR-429” and “HDAC2” should read “class II HDACs”. Additionally, in the second sentence of the second to last paragraph on p. 240 “HDAC2” should read “class II HDACs”. Finally, reference [54] should not appear in the third sentence of the third paragraph under the section heading “miRNA activity in spinal systems and its involvement in chronic pain”. Full-Text PDF" @default.
• W2040484651 created "2016-06-24" @default.
• W2040484651 creator A5029241280 @default.
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• W2040484651 date "2015-04-01" @default.
• W2040484651 modified "2023-10-11" @default.
• W2040484651 title "Epigenetic mechanisms of chronic pain" @default.
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