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• W2040487718 endingPage "11108" @default.
• W2040487718 startingPage "11097" @default.
• W2040487718 abstract "The synthetic antimicrobial peptide CM15, a hybrid of N-terminal sequences from cecropin and melittin peptides, has been shown to be extremely potent. Its mechanism of action has been thought to involve pore formation based on prior site-directed spin labeling studies. This study examines four single-site β-thiocyanatoalanine variants of CM15 in which the artificial amino acid side chain acts as a vibrational reporter of its local environment through the frequency and line shape of the unique CN stretching band in the infrared spectrum. Circular dichroism experiments indicate that the placements of the artificial side chain have only small perturbative effects on the membrane-bound secondary structure of the CM15 peptide. All variant peptides were placed in buffer solution, in contact with dodecylphosphatidylcholine micelles, and in contact with vesicles formed from Escherichia coli polar lipid extract. At each site, the CN stretching band reports a different behavior. Time-dependent attenuated total reflectance infrared spectra were also collected for each variant as it was allowed to remodel the E. coli lipid vesicles. The results of these experiments agree with the previously proposed formation of toroidal pores, in which each peptide finds itself in an increasingly homogeneous and curved local environment without apparent peptide–peptide interactions. This work also demonstrates the excellent sensitivity of the SCN stretching vibration to small changes in the peptide–lipid interfacial structure." @default.
• W2040487718 created "2016-06-24" @default.
• W2040487718 creator A5009203134 @default.
• W2040487718 creator A5045926563 @default.
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• W2040487718 date "2011-12-02" @default.
• W2040487718 modified "2023-10-17" @default.
• W2040487718 title "Using Infrared Spectroscopy of Cyanylated Cysteine To Map the Membrane Binding Structure and Orientation of the Hybrid Antimicrobial Peptide CM15" @default.
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• W2040487718 doi "https://doi.org/10.1021/bi200903p" @default.
• W2040487718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3246368" @default.
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• W2040487718 hasPublicationYear "2011" @default.
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