FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040488932> ?p ?o ?g. }

• W2040488932 abstract "Cystic fibrosis (CF) lung disease begins in early life and is progressive with the major risk factor being an exaggerated inflammatory response. Currently, assessment of neutrophilic inflammation in early cystic fibrosis (CF) lung disease relies on bronchoalveolar lavage (BAL). The chitinase-like protein YKL-40 is raised in sputum and serum of adults with CF. We investigated YKL-40 in BAL, serum and urine to determine whether this reflected inflammation and infection in young children with CF. YKL-40 was measured in matched samples of BAL, serum and urine obtained from 36 infants and young children with CF participating in an early surveillance program. Levels were compared to clinical data and markers of inflammation detected in the lung. YKL-40 in BAL correlated with pulmonary infection [β=1.30 (SE 0.34), p < 0.001] and BAL markers of inflammation [macrophage number: r2 = 0.34, p < 0.001; neutrophil number: r2 = 0.74, p < 0.001; neutrophil elastase: r2 = 0.47, p < 0.001; CXCL8: r2 = 0.45, p < 0.001; IL-β: r2 = 0.62, p < 0.001]. YKL-40 was detectable in serum but levels did not correlate with BAL levels in the same individuals (r2 = 0.04, p = 0.14) or with inflammatory markers. YKL-40 was below the limit of detection in urine (30 pg/ml). This study demonstrates that levels of the chitinase-like protein YKL-40 reflect airway inflammation and infection in early CF lung disease. The lack of increased YKL-40 in serum in the absence of systemic inflammation limits the benefit of this potential biomarker in early disease." @default.
• W2040488932 created "2016-06-24" @default.
• W2040488932 creator A5010666755 @default.
• W2040488932 creator A5023641403 @default.
• W2040488932 creator A5048175603 @default.
• W2040488932 creator A5065440971 @default.
• W2040488932 date "2014-02-27" @default.
• W2040488932 modified "2023-10-18" @default.
• W2040488932 title "Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease" @default.
• W2040488932 cites W1971128882 @default.
• W2040488932 cites W1982167473 @default.
• W2040488932 cites W1983495472 @default.
• W2040488932 cites W1995945093 @default.
• W2040488932 cites W2009626868 @default.
• W2040488932 cites W2011497901 @default.
• W2040488932 cites W2023456873 @default.
• W2040488932 cites W2048363480 @default.
• W2040488932 cites W2049079346 @default.
• W2040488932 cites W2054173689 @default.
• W2040488932 cites W2054704409 @default.
• W2040488932 cites W2084902225 @default.
• W2040488932 cites W2099826543 @default.
• W2040488932 cites W2102558296 @default.
• W2040488932 cites W2105248725 @default.
• W2040488932 cites W2112740712 @default.
• W2040488932 cites W2119974004 @default.
• W2040488932 cites W2120347156 @default.
• W2040488932 cites W2124361740 @default.
• W2040488932 cites W2125242373 @default.
• W2040488932 cites W2130622441 @default.
• W2040488932 cites W2130951311 @default.
• W2040488932 cites W2139536060 @default.
• W2040488932 cites W2142867489 @default.
• W2040488932 cites W2143808244 @default.
• W2040488932 cites W2145163797 @default.
• W2040488932 cites W2149842375 @default.
• W2040488932 cites W2166476126 @default.
• W2040488932 cites W2167279949 @default.
• W2040488932 cites W2168073966 @default.
• W2040488932 doi "https://doi.org/10.1186/1471-2466-14-28" @default.
• W2040488932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3946043" @default.
• W2040488932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24576297" @default.
• W2040488932 hasPublicationYear "2014" @default.
• W2040488932 type Work @default.
• W2040488932 sameAs 2040488932 @default.
• W2040488932 citedByCount "22" @default.
• W2040488932 countsByYear W20404889322014 @default.
• W2040488932 countsByYear W20404889322015 @default.
• W2040488932 countsByYear W20404889322016 @default.
• W2040488932 countsByYear W20404889322017 @default.
• W2040488932 countsByYear W20404889322018 @default.
• W2040488932 countsByYear W20404889322020 @default.
• W2040488932 countsByYear W20404889322021 @default.
• W2040488932 countsByYear W20404889322022 @default.
• W2040488932 countsByYear W20404889322023 @default.
• W2040488932 crossrefType "journal-article" @default.
• W2040488932 hasAuthorship W2040488932A5010666755 @default.
• W2040488932 hasAuthorship W2040488932A5023641403 @default.
• W2040488932 hasAuthorship W2040488932A5048175603 @default.
• W2040488932 hasAuthorship W2040488932A5065440971 @default.
• W2040488932 hasBestOaLocation W20404889321 @default.
• W2040488932 hasConcept C126322002 @default.
• W2040488932 hasConcept C142724271 @default.
• W2040488932 hasConcept C203014093 @default.
• W2040488932 hasConcept C2776301714 @default.
• W2040488932 hasConcept C2776317360 @default.
• W2040488932 hasConcept C2776914184 @default.
• W2040488932 hasConcept C2776938444 @default.
• W2040488932 hasConcept C2777714996 @default.
• W2040488932 hasConcept C2777961210 @default.
• W2040488932 hasConcept C2780026642 @default.
• W2040488932 hasConcept C2781069245 @default.
• W2040488932 hasConcept C71924100 @default.
• W2040488932 hasConcept C77411442 @default.
• W2040488932 hasConcept C90924648 @default.
• W2040488932 hasConceptScore W2040488932C126322002 @default.
• W2040488932 hasConceptScore W2040488932C142724271 @default.
• W2040488932 hasConceptScore W2040488932C203014093 @default.
• W2040488932 hasConceptScore W2040488932C2776301714 @default.
• W2040488932 hasConceptScore W2040488932C2776317360 @default.
• W2040488932 hasConceptScore W2040488932C2776914184 @default.
• W2040488932 hasConceptScore W2040488932C2776938444 @default.
• W2040488932 hasConceptScore W2040488932C2777714996 @default.
• W2040488932 hasConceptScore W2040488932C2777961210 @default.
• W2040488932 hasConceptScore W2040488932C2780026642 @default.
• W2040488932 hasConceptScore W2040488932C2781069245 @default.
• W2040488932 hasConceptScore W2040488932C71924100 @default.
• W2040488932 hasConceptScore W2040488932C77411442 @default.
• W2040488932 hasConceptScore W2040488932C90924648 @default.
• W2040488932 hasIssue "1" @default.
• W2040488932 hasLocation W20404889321 @default.
• W2040488932 hasLocation W20404889322 @default.
• W2040488932 hasLocation W20404889323 @default.
• W2040488932 hasLocation W20404889324 @default.
• W2040488932 hasOpenAccess W2040488932 @default.
• W2040488932 hasPrimaryLocation W20404889321 @default.
• W2040488932 hasRelatedWork W1976318640 @default.
• W2040488932 hasRelatedWork W1990846908 @default.
• W2040488932 hasRelatedWork W2055347946 @default.
• W2040488932 hasRelatedWork W2066503600 @default.

• next