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- W2040492050 abstract "B ECAUSE the cellular regulation of sodium and other ions has been implicated in the pathogenesis and maintenance of hypertension, the study of ion transport has captured the attention of many researchers interested in the pathophysiology of hypertension. Several investigators have proposed that sodium metabolism by the kidney, not sodium intake, is the critical issue underlying the observed differences in the prevalence and characteristics of hypertension between blacks and whites in the United States. I Evaluation of racial/ethnic phenotypic differences in ion transport has provided data that suggest mechanisms by which a genetic or environmental factors may contribute to the twofold excess of hypertension in US blacks compared with whites. A caveat inherent in the interpretation of studies of racial differences relates to the genetic admixture of populations in the United States. Despite this limitation, however, certain trends have become apparent. Assessment of black/white differences in intracellular cations has pointed to sodium as the cation that is most consistently abnormal. Sodium interacts with other cations, notably calcium, and various cellular transport systems to increase vascular reactivity, often considered the basic pathway to essential hypertension. The primary mechanism proposed by a number of investigators whereby hypertension develops in this setting is that higher intracellular sodium increases activity of the sodium-calcium exchanger (Fig 1), thereby increasing intracellular calcium. The net effect is to enhance responsiveness to vasoactive" @default.
- W2040492050 created "2016-06-24" @default.
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- W2040492050 date "1993-04-01" @default.
- W2040492050 modified "2023-09-26" @default.
- W2040492050 title "Ethnic Differences in Cellular Ions and Transport" @default.
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- W2040492050 doi "https://doi.org/10.1016/s0272-6386(12)80861-4" @default.
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