Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040493845> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2040493845 endingPage "239" @default.
- W2040493845 startingPage "233" @default.
- W2040493845 abstract "A novel reversed-phase ultra high performance liquid chromatography coupled with high resolution quantitation mass spectrometry (UHPLC/HRQMS) method was developed to quantify 2,5-dichlorobenzoyl chloride (DCBC), a genotoxic impurity, in MLN9708 drug substance. A surrogate strategy was utilized whereby DCBC was intentionally hydrolyzed to 2,5-dichlorobenzoic acid (DCBA) to provide a stable and reliable detection target. The hydrolysis approach was conservative since the measured signal represented the sum of DCBC and DCBA in MLN9708 drug substance, and such approach was acknowledged and accepted by food and drug administration (FDA). HRQMS was used as the detection method since conventional MS/MS methodology gave poor sensitivity and selectivity due to non-specific fragmentation of carbon dioxide loss upon collision activation dissociation. Profile algorithm mass spectrometry data were acquired with mass resolving power (MRP) of 60,000. Quantitation was based on the extracted ion chromatography (EIC) peak area signal, which was extracted at m/z 188.9515 with a mass extraction window (MEW) of 5ppm. The UHPLC/HRQMS method was validated based on International Conference on Harmonization (ICH) guidelines, which included selectivity, limit of detection (LOD), limit of quantitation (LOQ), repeatability, linearity, accuracy, and stability." @default.
- W2040493845 created "2016-06-24" @default.
- W2040493845 creator A5004634182 @default.
- W2040493845 creator A5006165632 @default.
- W2040493845 creator A5049631267 @default.
- W2040493845 creator A5080858466 @default.
- W2040493845 date "2014-02-01" @default.
- W2040493845 modified "2023-09-27" @default.
- W2040493845 title "Ultra high performance liquid chromatography coupled with high resolution quantitation mass spectrometry method development and validation for determining genotoxic 2,5-dichlorobenzoyl chloride in MLN9708 drug substance" @default.
- W2040493845 cites W1601524935 @default.
- W2040493845 cites W1964915638 @default.
- W2040493845 cites W1970481885 @default.
- W2040493845 cites W1995470869 @default.
- W2040493845 cites W2006581393 @default.
- W2040493845 cites W2007221050 @default.
- W2040493845 cites W2007686088 @default.
- W2040493845 cites W2014590342 @default.
- W2040493845 cites W2024429336 @default.
- W2040493845 cites W2030809936 @default.
- W2040493845 cites W2043293873 @default.
- W2040493845 cites W2045999249 @default.
- W2040493845 cites W2050740972 @default.
- W2040493845 cites W2096207943 @default.
- W2040493845 cites W2106692847 @default.
- W2040493845 cites W2108235071 @default.
- W2040493845 cites W2109371953 @default.
- W2040493845 cites W2131001551 @default.
- W2040493845 cites W2148690874 @default.
- W2040493845 cites W2154157119 @default.
- W2040493845 doi "https://doi.org/10.1016/j.jpba.2013.11.012" @default.
- W2040493845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24309557" @default.
- W2040493845 hasPublicationYear "2014" @default.
- W2040493845 type Work @default.
- W2040493845 sameAs 2040493845 @default.
- W2040493845 citedByCount "9" @default.
- W2040493845 countsByYear W20404938452014 @default.
- W2040493845 countsByYear W20404938452015 @default.
- W2040493845 countsByYear W20404938452016 @default.
- W2040493845 countsByYear W20404938452017 @default.
- W2040493845 countsByYear W20404938452018 @default.
- W2040493845 countsByYear W20404938452019 @default.
- W2040493845 countsByYear W20404938452021 @default.
- W2040493845 crossrefType "journal-article" @default.
- W2040493845 hasAuthorship W2040493845A5004634182 @default.
- W2040493845 hasAuthorship W2040493845A5006165632 @default.
- W2040493845 hasAuthorship W2040493845A5049631267 @default.
- W2040493845 hasAuthorship W2040493845A5080858466 @default.
- W2040493845 hasConcept C113196181 @default.
- W2040493845 hasConcept C118792377 @default.
- W2040493845 hasConcept C119128265 @default.
- W2040493845 hasConcept C154020017 @default.
- W2040493845 hasConcept C161790260 @default.
- W2040493845 hasConcept C162356407 @default.
- W2040493845 hasConcept C178790620 @default.
- W2040493845 hasConcept C185592680 @default.
- W2040493845 hasConcept C43617362 @default.
- W2040493845 hasConceptScore W2040493845C113196181 @default.
- W2040493845 hasConceptScore W2040493845C118792377 @default.
- W2040493845 hasConceptScore W2040493845C119128265 @default.
- W2040493845 hasConceptScore W2040493845C154020017 @default.
- W2040493845 hasConceptScore W2040493845C161790260 @default.
- W2040493845 hasConceptScore W2040493845C162356407 @default.
- W2040493845 hasConceptScore W2040493845C178790620 @default.
- W2040493845 hasConceptScore W2040493845C185592680 @default.
- W2040493845 hasConceptScore W2040493845C43617362 @default.
- W2040493845 hasLocation W20404938451 @default.
- W2040493845 hasLocation W20404938452 @default.
- W2040493845 hasOpenAccess W2040493845 @default.
- W2040493845 hasPrimaryLocation W20404938451 @default.
- W2040493845 hasRelatedWork W1531075780 @default.
- W2040493845 hasRelatedWork W1980714464 @default.
- W2040493845 hasRelatedWork W1987023309 @default.
- W2040493845 hasRelatedWork W2020128413 @default.
- W2040493845 hasRelatedWork W2055701698 @default.
- W2040493845 hasRelatedWork W2060124471 @default.
- W2040493845 hasRelatedWork W2061951347 @default.
- W2040493845 hasRelatedWork W2472192826 @default.
- W2040493845 hasRelatedWork W2474504792 @default.
- W2040493845 hasRelatedWork W3179568669 @default.
- W2040493845 hasVolume "89" @default.
- W2040493845 isParatext "false" @default.
- W2040493845 isRetracted "false" @default.
- W2040493845 magId "2040493845" @default.
- W2040493845 workType "article" @default.