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- W2040498839 abstract "We studied whether therapeutic doses of cyclosporin A (CsA) modify the effects of nutrient and non-nutrient stimuli on pHi, in the insulin-secreting β-cell line HIT-T 15. Glucose caused a transient acidification, followed by alkanization. CsA failed to block this alkalinization. PMA elicited a gradual alkalinization by a protein kinase C mediated mechanism which is not inhibited by CsA. The despolarization with high K+ was associated with a rise in PHi. CsA was able to completely block this increase in pHi. Ionomycin induced a rapid cytosolic alkalinization partially inhibited by CsA. We conclude that in HIT-T 15 cells therapeutical doses of CsA inhibit the Ca2+-dependent pathway of Na+/H+ antiport activation but not protein kinase C activation of this exchanger." @default.
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- W2040498839 date "1992-01-01" @default.
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- W2040498839 title "Effects of cyclosporin a on induced hit cell alkalinization" @default.
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- W2040498839 doi "https://doi.org/10.1016/0024-3205(92)90230-m" @default.
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