Matches in SemOpenAlex for { <https://semopenalex.org/work/W2040500601> ?p ?o ?g. }
- W2040500601 endingPage "1558" @default.
- W2040500601 startingPage "1558" @default.
- W2040500601 abstract "Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits its clinical application. Nanotechnology provides an effective method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL micelles were monodisperse (PDI = 0.097 ± 0.011) with a mean particle size of 27.3 ± 1.3 nm, good re-solubility after freeze-drying, an encapsulation efficiency of 99.16 ± 1.02%, and drug loading of 12.95 ± 0.15%. Moreover, these micelles were prepared by a simple and reproducible procedure, making them potentially suitable for scale-up. Curcumin was molecularly dispersed in the PCL core of MPEG-PCL micelles, and could be slow-released in vitro. Encapsulation of curcumin in MPEG-PCL micelles improved the t1/2 and AUC of curcuminin vivo. As well as free curcumin, Cur/MPEG-PCL micelles efficiently inhibited the angiogenesis on transgenic zebrafish model. In an alginate-encapsulated cancer cell assay, intravenous application of Cur/MPEG-PCL micelles more efficiently inhibited the tumor cell-induced angiogenesisin vivo than that of free curcumin. MPEG-PCL micelle-encapsulated curcumin maintained the cytotoxicity of curcumin on C-26 colon carcinoma cellsin vitro. Intravenous application of Cur/MPEG-PCL micelle (25 mg kg−1curcumin) inhibited the growth of subcutaneous C-26 colon carcinoma in vivo (p < 0.01), and induced a stronger anticancer effect than that of free curcumin (p < 0.05). In conclusion, Cur/MPEG-PCL micelles are an excellent intravenously injectable aqueous formulation of curcumin; this formulation can inhibit the growth of colon carcinoma through inhibiting angiogenesis and directly killing cancer cells." @default.
- W2040500601 created "2016-06-24" @default.
- W2040500601 creator A5001504110 @default.
- W2040500601 creator A5021210072 @default.
- W2040500601 creator A5029538972 @default.
- W2040500601 creator A5040621231 @default.
- W2040500601 creator A5044630652 @default.
- W2040500601 creator A5045703368 @default.
- W2040500601 creator A5049740688 @default.
- W2040500601 creator A5052503892 @default.
- W2040500601 creator A5067029768 @default.
- W2040500601 creator A5079311713 @default.
- W2040500601 date "2011-01-01" @default.
- W2040500601 modified "2023-10-11" @default.
- W2040500601 title "Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo" @default.
- W2040500601 cites W1559338548 @default.
- W2040500601 cites W1604068141 @default.
- W2040500601 cites W1664719478 @default.
- W2040500601 cites W175416543 @default.
- W2040500601 cites W1965565026 @default.
- W2040500601 cites W1972179974 @default.
- W2040500601 cites W1974439793 @default.
- W2040500601 cites W1976194786 @default.
- W2040500601 cites W1977533639 @default.
- W2040500601 cites W1980828424 @default.
- W2040500601 cites W1985229083 @default.
- W2040500601 cites W1991327193 @default.
- W2040500601 cites W1992652784 @default.
- W2040500601 cites W1999312756 @default.
- W2040500601 cites W1999910805 @default.
- W2040500601 cites W2010976109 @default.
- W2040500601 cites W2013372525 @default.
- W2040500601 cites W2022175849 @default.
- W2040500601 cites W2022438556 @default.
- W2040500601 cites W2028490063 @default.
- W2040500601 cites W2033629987 @default.
- W2040500601 cites W2035522858 @default.
- W2040500601 cites W2038009750 @default.
- W2040500601 cites W2044826456 @default.
- W2040500601 cites W2047503677 @default.
- W2040500601 cites W2051247936 @default.
- W2040500601 cites W2051381895 @default.
- W2040500601 cites W2056533846 @default.
- W2040500601 cites W2060688810 @default.
- W2040500601 cites W2062351951 @default.
- W2040500601 cites W2065252231 @default.
- W2040500601 cites W2080082999 @default.
- W2040500601 cites W2080573554 @default.
- W2040500601 cites W2088242076 @default.
- W2040500601 cites W2092032160 @default.
- W2040500601 cites W2112927879 @default.
- W2040500601 cites W2115586774 @default.
- W2040500601 cites W2121411068 @default.
- W2040500601 cites W2125943630 @default.
- W2040500601 cites W2127597456 @default.
- W2040500601 cites W2129397604 @default.
- W2040500601 cites W2134772436 @default.
- W2040500601 cites W2138184824 @default.
- W2040500601 cites W2138508372 @default.
- W2040500601 cites W2139981029 @default.
- W2040500601 cites W2141474275 @default.
- W2040500601 cites W2147905076 @default.
- W2040500601 cites W2147995249 @default.
- W2040500601 cites W2148706833 @default.
- W2040500601 cites W2156211060 @default.
- W2040500601 cites W2159702865 @default.
- W2040500601 cites W2167789852 @default.
- W2040500601 cites W2170079210 @default.
- W2040500601 cites W2315026653 @default.
- W2040500601 doi "https://doi.org/10.1039/c0nr00758g" @default.
- W2040500601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21283869" @default.
- W2040500601 hasPublicationYear "2011" @default.
- W2040500601 type Work @default.
- W2040500601 sameAs 2040500601 @default.
- W2040500601 citedByCount "348" @default.
- W2040500601 countsByYear W20405006012012 @default.
- W2040500601 countsByYear W20405006012013 @default.
- W2040500601 countsByYear W20405006012014 @default.
- W2040500601 countsByYear W20405006012015 @default.
- W2040500601 countsByYear W20405006012016 @default.
- W2040500601 countsByYear W20405006012017 @default.
- W2040500601 countsByYear W20405006012018 @default.
- W2040500601 countsByYear W20405006012019 @default.
- W2040500601 countsByYear W20405006012020 @default.
- W2040500601 countsByYear W20405006012021 @default.
- W2040500601 countsByYear W20405006012022 @default.
- W2040500601 countsByYear W20405006012023 @default.
- W2040500601 crossrefType "journal-article" @default.
- W2040500601 hasAuthorship W2040500601A5001504110 @default.
- W2040500601 hasAuthorship W2040500601A5021210072 @default.
- W2040500601 hasAuthorship W2040500601A5029538972 @default.
- W2040500601 hasAuthorship W2040500601A5040621231 @default.
- W2040500601 hasAuthorship W2040500601A5044630652 @default.
- W2040500601 hasAuthorship W2040500601A5045703368 @default.
- W2040500601 hasAuthorship W2040500601A5049740688 @default.
- W2040500601 hasAuthorship W2040500601A5052503892 @default.
- W2040500601 hasAuthorship W2040500601A5067029768 @default.
- W2040500601 hasAuthorship W2040500601A5079311713 @default.